"They were already inside my head to begin with": Trust, Translational Misconception, and Intraoperative Brain Research.
"They were already inside my head to begin with": Trust, Translational Misconception, and Intraoperative Brain Research.
复制标题
“它们一开始就在我的脑海里”：信任、转化误解和术中大脑研究。
DOI：
10.1080/23294515.2022.2123869
复制
发表时间：
2023
影响因子：
--
通讯作者：
Feinsinger,Ashley
中科院分区：
文献类型：
--
作者：
PeabodySmith,Ally;Taiclet,Lauren;Ebadi,Hamasa;Levy,Lilyana;Weber,Megan;Caruso,EugeneM;Pouratian,Nader;Feinsinger,Ashley
背景：接受侵入性神经外科手术的患者为研究人员提供了研究大脑的独特机会。例如，深部脑刺激患者可以在刺激器装置的手术植入期间参与研究。虽然这项研究提出了许多伦理问题，很少有人关注的基础研究，这提供了没有治疗的好处，和病人参与者的perspectives.Methods的价值：半结构化的采访进行了14个人在两项研究谁参加了基础术中研究在他们的脑深部电刺激器手术。访谈探讨了风险和收益的解释，入学动机，以及参与清醒大脑研究的经验。自反性主题分析carried.Results：七个主题被确定从参与者的叙述，包括强大的信任态度，高评价的基础科学研究，影响的手术背景下，和混合的经验participation.Conclusion：我们认为，这些叙述提高了潜在的翻译误解和动机术中重新同意程序。
Background:Patients undergoing invasive neurosurgical procedures offer researchers unique opportunities to study the brain. Deep brain stimulation patients, for example, may participate in research during the surgical implantation of the stimulator device. Although this research raises many ethical concerns, little attention has been paid to basic studies, which offer no therapeutic benefits, and the value of patient-participant perspectives.Methods:Semi-structured interviews were conducted with fourteen individuals across two studies who participated in basic intraoperative research during their deep brain stimulator surgery. Interviews explored interpretations of risks and benefits, enrollment motivations, and experiences of participating in awake brain research. Reflexive thematic analysis was conducted.Results:Seven themes were identified from participant narratives, including robust attitudes of trust, high valuations of basic science research, impacts of the surgical context, and mixed experiences of participation.Conclusion:We argue that these narratives raise the potential for a translational misconception and motivate intraoperative re-consent procedures.