Patterns of Antidepressant Medication Use Among Pregnant Women in a United States Population
Patterns of Antidepressant Medication Use Among Pregnant Women in a United States Population
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DOI：
10.1177/0091270010373928
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发表时间：
2011-02-01
影响因子：
2.9
通讯作者：
Friedman, Jan M.
中科院分区：
文献类型：
--
作者：
Alwan, Sura;Reefhuis, Jennita;Friedman, Jan M.
本文描述了在一个基于人群的样本中，分娩无出生缺陷的活产婴儿的妇女在怀孕期间使用抗抑郁药的模式。数据来自国家出生缺陷预防研究，这是一项正在进行的出生缺陷风险因素病例对照研究，覆盖美国10个州。在1998年至2005年期间出生的无出生缺陷的活产婴儿（对照组）的母亲从每个地点随机选择。通过标准化的电话访谈收集母亲的特征和抗抑郁药暴露的信息。在6582名母亲中，298名（4.5%）报告在怀孕前3个月至妊娠结束期间使用抗抑郁药。最常报告使用选择性5-羟色胺再吸收抑制剂（3.8%），其次是安非他酮（0.7%）。在怀孕后的第一个月和第二个月之间，抗抑郁药的使用率从3.1%下降到2.3%（P <0.001）。在4个州，报告的妊娠期间任何时间使用抗抑郁药的频率从1998年的2.5%增加到2005年的8.1%（P <0.001）。研究结果显示，在9年的时间里，报告的抗抑郁药使用量增加，而在通常的怀孕识别时间前后，使用量大幅减少。
This article describes the pattern of reported antidepressant use around the time of pregnancy in a population-based sample of women who delivered live-born babies without birth defects. Data were used from the National Birth Defects Prevention Study, an ongoing case-control study of risk factors for birth defects covering 10 US states. Mothers of live-born infants without birth defects (controls) born between 1998 and 2005 were randomly selected from each site. Information on the mother's characteristics and exposure to antidepressants was collected via a standardized telephone interview. Among 6582 mothers included in the study, 298 (4.5%) reported use of an antidepressant in the period of 3 months before through the end of pregnancy. Use of selective serotonin-reuptake inhibitors was reported most often (3.8%), followed by bupropion (0.7%). A statistically significant decline was observed, from 3.1% to 2.3% (P < .001), in reported use of antidepressants between the first and second month after conception. The frequency of reported antidepressant use at any time during pregnancy increased from 2.5% in 1998 to 8.1% in 2005 (P < .001) in 4 states. The findings show an increase in reported antidepressant use over a 9-year period and a substantial decrease in use around the usual time of pregnancy recognition.