Patterning events and specification signals in the developing hippocampus
Patterning events and specification signals in the developing hippocampus
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DOI：
10.1093/cercor/9.6.551
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发表时间：
1999-09-01
期刊：
影响因子：
3.7
通讯作者：
Tole, S
中科院分区：
文献类型：
--
作者：
Grove, EA;Tole, S
小鼠海马是一个有吸引力的模型系统，在其中研究的图案的皮层结构。正在进行的研究表明，海马区或领域是指定的许多天前出生可能涉及的信号，从皮层地幔。虽然海马CA领域的区别，只有出生后的细胞结构，领域之间的分子差异出现妊娠晚期。此外，这些胚胎油田已经被指定为发展成熟油田的特征。海马体的基本区域划分可能在更早的时候就已经说明了。因此，如果内侧皮层神经上皮细胞在海马神经发生的早期在体外分离，它可以自主地产生图案化海马的功能。在体内，初始领域分化的空间进展表明，信号调节生长和图案可能会出现从接近海马两极的来源。对突变小鼠的观察表明，皮层边缘（一种靠近海马体一极的胚胎结构）是这种调节信号的来源。
The mouse hippocampus is an attractive model system in which to study patterning of a cortical structure. Ongoing studies indicate that hippocampal areas or fields are specified many days before birth possibly involving signals from within the cortical mantle. Although the hippocampal CA fields are distinguished by cytoarchitecture only after birth, molecular differences between fields appear by late gestation. Moreover, these embryonic fields are already specified to develop additional features that characterize the mature fields. The basic division of the hippocampus into fields may he specified still earlier. Thus, if medial cortical neuroepithelium is isolated in vitro early in hippocampal neurogenesis, it can autonomously generate features of a patterned hippocampus. In vivo, the spatial progression of initial field differentiation suggests that signals regulating growth and patterning could arise from sources close to the hippocampal poles. Observations of mouse mutants indicate that the cortical hem, an embryonic structure close to one pole of the hippocampus, is a source of such regulatory signals.