Optofluidic devices with integrated solid-state nanopores.
Optofluidic devices with integrated solid-state nanopores.
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DOI：
10.1007/s00604-016-1758-y
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Schmidt H
中科院分区：
文献类型：
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作者：
Liu S;Hawkins AR;Schmidt H
本文综述（参考文献90篇）涵盖了用于检测和传感的具有集成固态纳米孔的光流体器件的现有技术。在介绍了光流体学和固态纳米孔技术的原理之后，我们讨论了使用光流体学的基于固态纳米孔的测定的特征。这包括将固态纳米孔结合到基于液芯抗共振反射光波导（ARROW）的光流体平台中，其制造方法，单粒子检测和粒子操纵的方面。然后，我们描述了集成到光流控芯片的固态纳米孔所提供的新功能，特别是作为相关的光电检测和纳米粒子的歧视的智能门。这使得能够识别病毒和λ-DNA，粒子轨迹模拟，通过调整纳米孔的形状来提高灵敏度。审查结束时，总结和展望。
This review (with 90 refs.) covers the state of the art in optofluidic devices with integrated solid-state nanopores for use in detection and sensing. Following an introduction into principles of optofluidics and solid-state nanopore technology, we discuss features of solid-state nanopore based assays using optofluidics. This includes the incorporation of solid-state nanopores into optofluidic platforms based on liquid-core anti-resonant reflecting optical waveguides (ARROWs), methods for their fabrication, aspects of single particle detection and particle manipulation. We then describe the new functionalities provided by solid-state nanopores integrated into optofluidic chips, in particular acting as smart gates for correlated electro-optical detection and discrimination of nanoparticles. This enables the identification of viruses and λ-DNA, particle trajectory simulations, enhancing sensitivity by tuning the shape of nanopores. The review concludes with a summary and an outlook.