Opiate withdrawal modifies synaptic plasticity in subicular-nucleus accumbens pathway in vivo
Opiate withdrawal modifies synaptic plasticity in subicular-nucleus accumbens pathway in vivo
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阿片戒断改变体内伏核下通路的突触可塑性
DOI：
10.1016/j.neuroscience.2006.10.018
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发表时间：
2007-02-09
期刊：
影响因子：
3.3
通讯作者：
Xu, L.
中科院分区：
文献类型：
--
作者：
Dong, Z.;Cao, J.;Xu, L.
下托接收海马CAI神经元的输出，并将谷氨酸能突触投射到伏隔核（NAc），这是连接记忆和奖励系统的下托-NAc通路。吗啡戒断是否影响下丘脑NAc通路的突触可塑性尚不清楚。在此，我们记录了场兴奋性突触后电位（EPSP）内的壳NAc通过刺激腹侧下托在麻醉的成年大鼠。我们发现，高频刺激（HFS，200 Hz）诱导长时程增强（LTP），而低频刺激（LFS，1 Hz）未能诱导长时程抑制（LTD）。然而，行为应激使LFS能够诱导依赖于糖皮质激素受体的可靠LTD（sLTD）。LTP和sLTD均被N甲基-D-天冬氨酸受体拮抗剂AP-5阻止。在重复吗啡治疗12天后，急性戒断（12小时）损害LTP，但对sLTD没有影响;延长戒断（4天）恢复LTP，但损害sLTD。值得注意的是，基线EPSP振幅反映的基础突触功效在急性戒断中增强，但在长期戒断中被抑制。因此，急性和长期的阿片戒断可能会导致内源性LTP和LTD的下丘脑-NAc通路，阻塞随后的诱导突触可塑性，表现出适应性变化的NAc功能在阿片戒断。(c)2006年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Subiculum receives output of hippocampal CAI neurons and projects glutamatergic synapses onto nucleus accumbens (NAc), the subicular-NAc pathway linking memory and reward system. It is unknown whether morphine withdrawal influences synaptic plasticity in the subicularNAc pathway. Here, we recorded the field excitatory postsynaptic potential (EPSP) within the shell of NAc by stimulating ventral subiculum in anesthetized adult rats. We found that high frequency stimulation (HFS, 200 Hz) induced long-term potentiation (LTP) but low frequency stimulation (LFS, 1 Hz) failed to induce long-term depression (LTD) in control animals. However, behavioral stress enabled LFS to induce a reliable LTD (sLTD) that was dependent on the glucocorticoid receptors. Both LTP and sLTD were prevented by the Nmethyl-D-aspartate receptor antagonist AP-5. After repeated morphine treatment for 12 days, acute withdrawal (12 h) impaired LTP but had no effect on sLTD; prolonged withdrawal (4 days) restored the LTP but impaired the sLTD. Remarkably, basal synaptic efficacy reflected by baseline EPSP amplitude was potentiated in acute withdrawal but was depressed in prolonged withdrawal. Thus, acute and prolonged opiate withdrawal may cause endogenous LTP and LTD in the subicular-NAc pathway that occludes the subsequent induction of synaptic plasticity, demonstrating adaptive changes of the NAc functions during opiate withdrawal. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.