Interactions between idiothetic cues and external landmarks in the control of place cells and head direction cells
Interactions between idiothetic cues and external landmarks in the control of place cells and head direction cells
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DOI：
10.1152/jn.1998.80.1.425
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发表时间：
1998-07-01
影响因子：
2.5
通讯作者：
McNaughton, BL
中科院分区：
文献类型：
--
作者：
Knierim, JJ;Kudrimoti, HS;McNaughton, BL
大鼠大脑中有两种类型的神经元参与空间学习和导航：位置细胞，它在环境的特定位置有选择性地放电，可能构成认知地图的关键元素;头部方向细胞，当大鼠的头部指向特定方向时有选择性地放电，可能作为内部指南针来定位认知地图。这些细胞的空间和方向选择性的属性来自于外部地标输入和独特线索之间的复杂相互作用;然而，这种相互作用的确切性质知之甚少。为了解决这个问题，从视觉地标的方向信息被放置在直接冲突的方向信息从独特的线索。当两个信息源之间的不匹配很小时（45度），视觉地标对位置细胞的放电特性具有鲁棒的控制;然而，当不匹配较大时，位置细胞的放电场发生根本性的改变，海马形成了对环境的新表示。同样，视觉线索控制的头部方向细胞的发射特性时，不匹配是小的（45度），但独特的输入通常占主导地位的视觉地标时，不匹配较大。在某些条件下，当视觉标志占主导地位后，一个大的失配，总是有一个延迟之前的视觉线索施加控制的头部方向细胞。这些结果支持最近的模型提出，预先布线的内在连接，使独特的线索，作为主要的驱动器上的位置细胞和头部方向细胞，而可修改的外在连接介导的学习，视觉地标的次要影响。
Two types of neurons in the rat brain have been proposed to participate in spatial learning and navigation: place cells, which fire selectively in specific locations of an environment and which may constitute key elements of cognitive maps, and head direction cells, which fire selectively when the rat's head is pointed in a specific direction and which may serve as an internal compass to orient the cognitive map. The spatially and directionally selective properties of these cells arise from a complex interaction between input from external landmarks and from idiothetic cues; however, the exact nature of this interaction is poorly understood. To address this issue, directional information from visual landmarks was placed in direct conflict with directional information from idiothetic cues. When the mismatch between the two sources of information was small (45 degrees), the visual landmarks had robust control over the firing properties of place cells; when the mismatch was larger, however, the firing fields of the place cells were altered radically, and the hippocampus formed a new representation of the environment. Similarly, the visual cues had control over the firing properties of head direction cells when the mismatch was small (45 degrees), but the idiothetic input usually predominated over the visual landmarks when the mismatch was larger. Under some conditions, when the visual landmarks predominated after a large mismatch, there was always a delay before the visual cues exerted their control over head direction cells. These results support recent models proposing that prewired intrinsic connections enable idiothetic cues to serve as the primary drive on place cells and head direction cells, whereas modifiable extrinsic connections mediate a learned, secondary influence of visual landmarks.