Hg(OTf)_2-Catalyzed Direct Vinylation of Tryptamines and Versatile Applications for Tandem Reactions
Hg(OTf)_2-Catalyzed Direct Vinylation of Tryptamines and Versatile Applications for Tandem Reactions
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Hg(OTf)_2-催化色胺的直接乙烯基化及其串联反应的多种应用
DOI：
10.1039/c2ob25236h
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发表时间：
2012
影响因子：
3.2
通讯作者：
Hiroki Oguri
中科院分区：
文献类型：
--
作者：
Haruki Mizoguchi;Hideaki Oikawa;Hiroki Oguri
我们已经开发了一种独特的催化协议，直接gem-vinylation色胺衍生物采用Hg（OTf）2作为最佳催化剂。在室温下，吲哚类化合物的C2位与一系列芳香炔类化合物进行了分子间乙烯化反应。在此基础上，我们进一步发展了串联反应，成功地构建了一个四元中心。
We have developed a unique catalytic protocol for direct gem-vinylation of tryptamine derivatives employing Hg(OTf)2 as the optimum catalyst. The intermolecular vinylations with a series of aromatic acetylenes proceeded under ambient temperature at the C2 positions of indoles with high functional group tolerance. Based on the mechanistic insights, we further developed the tandem reactions successfully constructing a quaternary center.