A model for the modulation of microvessel permeability by junction strands.
A model for the modulation of microvessel permeability by junction strands.
复制标题
通过连接链调节微血管通透性的模型。
DOI：
10.1115/1.1611514
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Chen,Bin
中科院分区：
文献类型：
--
作者：
Fu,BingmeiM;Chen,Bin
为了研究连接链对微血管通透性的影响，我们扩展了Fu等人（1994，J. Biomech.工程师：116，pp. 502-513），使内皮间裂包括裂中的多个连接链以及表面糖萼层和裂入口之间的界面。基于Adamson等人（1998，Am.生理学杂志，274（43），pp. H1885-H1894），细胞内cAMP水平升高会增加紧密连接链的数量，这种双连接链和双孔模型可以成功地解释cAMP降低水、小分子和中等分子溶质渗透性的实验数据。
To investigate the effect of junction strands on microvessel permeability, we extend the previous analytical model developed by Fu et al. (1994, J. Biomech. Eng.,116, pp. 502–513), for the interendothelial cleft to include multiple junction strands in the cleft and an interface between the surface glycocalyx layer and the cleft entrance. Based on the electron microscopic observations by Adamson et al. (1998, Am. J. Physiol.,274(43), pp. H1885–H1894), that elevation of intracellular cAMP levels would increase number of tight junction strands, this two-junction-strand and two-pore model can successfully account for the experimental data for the decreased permeability to water, small and intermediate-sized solutes by cAMP.