Topological optimization for designing patient-specific large craniofacial segmental bone replacements
Topological optimization for designing patient-specific large craniofacial segmental bone replacements
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DOI：
10.1073/pnas.1001208107
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发表时间：
2010-07-27
影响因子：
11.1
通讯作者：
Nguyen, Tam H.
中科院分区：
文献类型：
--
作者：
Sutradhar, Alok;Paulino, Glaucio H.;Nguyen, Tam H.
大面积面部损伤伴骨丢失后恢复正常的功能和外观是外科手术中尚未解决的重要问题。当前方法的一个重要局限性是由外科医生在手术时启发式地设计骨替代物。这个问题可以通过将一种称为拓扑优化的计算方法结合到常规手术计划中来解决。我们测试了使用多分辨率三维拓扑优化设计大面积面中损伤骨质流失替代物的可行性。满足功能需求的最终解决方案可能与天然人骨的形状不同，但可以根据功能需求进行优化，以支持使用软组织修复和合成假肢的组合进行完全修复。设计面部骨组织替代物的拓扑优化可能会改进当前的临床方法，并提供必要的使能技术，将通用的骨组织工程方法转化为针对个体患者的特定解决方案。
Restoring normal function and appearance after massive facial injuries with bone loss is an important unsolved problem in surgery. An important limitation of the current methods is heuristic ad hoc design of bone replacements by the operating surgeon at the time of surgery. This problem might be addressed by incorporating a computational method known as topological optimization into routine surgical planning. We tested the feasibility of using a multiresolution three-dimensional topological optimization to design replacements for massive midface injuries with bone loss. The final solution to meet functional requirements may be shaped differently than the natural human bone but be optimized for functional needs sufficient to support full restoration using a combination of soft tissue repair and synthetic prosthetics. Topological optimization for designing facial bone tissue replacements might improve current clinical methods and provide essential enabling technology to translate generic bone tissue engineering methods into specific solutions for individual patients.