Vascular maturity of type 1 and type 2 choroidal neovascularization evaluated by optical coherence tomography angiography
Vascular maturity of type 1 and type 2 choroidal neovascularization evaluated by optical coherence tomography angiography
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DOI：
10.1371/journal.pone.0216304
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发表时间：
2019-04-29
期刊：
影响因子：
3.7
通讯作者：
Terasaki, Hiroko
中科院分区：
文献类型：
--
作者：
Nakano, Yuyako;Kataoka, Keiko;Terasaki, Hiroko
目的导管成熟被认为是通过修剪树枝导致较少的分支导管来进行的。本研究探讨了1型和2型脉络膜新生血管（CNVs）使用光学相干断层扫描血管造影术（OCTA）的血管连接密度。MethodsWe收集了连续的数据，从治疗初治的眼睛诊断为典型的年龄相关性黄斑变性（AMD）。结果60例（60只眼）患者中，1型CNV 40只眼，2型CNV 20只眼。我们发现1型CNV和2型CNV之间的血管面积无显著差异（1型CNV，0.44 +/- 0.37 mm 2; 2型CNV，0.37 +/- 0.48 mm（2）），血管长度无显著差异（1型CNV，18.24 +/- 15.96 mm; 2型CNV，16.13 +/- 21.45 mm）。结论OCTA显示1型CNV的血管连接密度低于2型CNV，提示1型CNV血管比2型CNV血管成熟。
PurposeVessel maturation is considered to proceed by pruning branches resulting in less branching vessels. This study investigated the vessel junction densities of type 1 and type 2 choroidal neovascularizations (CNVs) using optical coherence tomography angiography (OCTA).MethodsWe collected consecutive data from treatment-naive eyes diagnosed with typical age-related macular degeneration (AMD). The OCTA images with CNV were analyzed to calculate vessel areas, vessel lengths, and vessel junction densities.ResultsOf 60 eyes in 60 patients, type 1 CNV diagnoses had been made in 40 eyes, and type 2 CNV in 20 eyes. We found no significant difference in vessel areas between type 1 CNV and type 2 CNV (type 1 CNV, 0.44 +/- 0.37 mm 2; type 2 CNV, 0.37 +/- 0.48 mm(2)), and no significant difference in vessel lengths (type 1 CNV, 18.24 +/- 15.96 mm; type 2 CNV, 16.13 +/- 21.45 mm). However, the vessel junction density of type 1 CNV was significantly lower than that of type 2 CNV by 16.0% (P = 0.008).ConclusionOCTA revealed that the vessel junction densities of type 1 CNVs were lower than those of type 2 CNVs, suggesting type 1 CNV vessels are more mature than type 2 CNV vessels.