SERUM IMMUNOGLOBULIN LEVELS IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA AND THEIR MOTHERS AND SIBS
SERUM IMMUNOGLOBULIN LEVELS IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA AND THEIR MOTHERS AND SIBS
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DOI：
10.1136/adc.47.254.618
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发表时间：
1972-01-01
影响因子：
5.2
通讯作者：
CHANDRA, RK
中科院分区：
文献类型：
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作者：
CHANDRA, RK
对29例急性淋巴细胞白血病患儿及其一级亲属进行了血清免疫球蛋白G、A和M测定。6例新生儿同胞脐血IgM水平较高。母亲血清中IgG和IgM升高，2 ~ 10岁同胞血清IgG明显降低。研究结果表明，在受影响的同胞的子宫内生活中存在一些抗原刺激，可能是病毒。据推测，免疫球蛋白异常可能与白血病的发病过程有关。
Serum immunoglobulins G, A, and M were estimated in 29 children with acute lymphoblastic leukaemia and their first-degree relatives. 6 newborn sibs had high IgM levels in cord blood. IgG and IgM were raised in the mothers' sera and there was a significant decrease in the serum IgG of sibs aged 2 to 10 years. The findings suggest the presence of some antigenic stimulus, possibly a virus, in the intrauterine life of affected sibships. It is postulated that the immunoglobulin abnormalities may be related pathogenetically to the leukaemic process.