ELEVATION OF OXYTOCIN AND THE OXYTOCIN-ASSOCIATED NEUROPHYSIN IN THE PLASMA OF NORMAL WOMEN DURING MID-CYCLE
ELEVATION OF OXYTOCIN AND THE OXYTOCIN-ASSOCIATED NEUROPHYSIN IN THE PLASMA OF NORMAL WOMEN DURING MID-CYCLE
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DOI：
10.1210/jcem-53-6-1229
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发表时间：
1981-01-01
影响因子：
5.8
通讯作者：
ROBINSON, AG
中科院分区：
文献类型：
--
作者：
AMICO, JA;SEIF, SM;ROBINSON, AG
在6名女性中，有5名女性的血浆中催产素和雌激素刺激神经physin (ESN)（催产素的蛋白质载体）水平与月经中期雌激素(E)升高呈正相关。最大E水平出现时间与催产素水平的相关性显著高于卵泡早期和黄体晚期（P < 0.025）。卵泡早期和黄体晚期回声状态网络（ESN）水平在卵泡中期显著高于卵泡早期和黄体晚期（P < 0.01）。除了哺乳期或妊娠期，这是人类唯一被描述的催产素循环分泌。由于催产素在时间上与月经中期E水平的上升相关，因此可以考虑催产素在排卵中的作用。
A positive correlation was observed between the midcycle elevation of estrogen (E) and the level of oxytocin- and estrogen-stimulated neurophysin (ESN), the protein carrier of oxytocin, in the plasma of 5 of 6 women. The time of the maximal level of E was associated with a level of oxytocin significantly greater than that in either the early follicular or late luteal phase (P < 0.025). Likewise, the level of ESN at midcycle was greater than the level of ESN in the early follicular or late luteal phase (P < 0.01). Other than states of lactation or pregnancy, this is the only described cyclic secretion of oxytocin in humans. Since oxytocin chronologically correlates with a rise in the level of E at midcycle, a role for oxytocin in ovulation may be considered.