Evaluation of molecular breast imaging in women undergoing myocardial perfusion imaging with Tc-99m sestamibi.
Evaluation of molecular breast imaging in women undergoing myocardial perfusion imaging with Tc-99m sestamibi.
复制标题
使用 Tc-99m 赛他米比进行心肌灌注成像的女性的分子乳腺成像评估。
DOI：
10.1089/jwh.2011.3267
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Michael K. O’Connor
中科院分区：
文献类型：
--
作者：
C. Hruska;D. Rhodes;Douglas A. Collins;Cindy L. Tortorelli;J. Wells Askew;Michael K. O’Connor
背景
我们的目的是探索分子乳腺成像（MBI）作为一种筛查技术对接受应激性心肌灌注研究的女性的潜在益处。
方法
向接受 Tc-99m 塞他米比注射的女性提供 MBI，以进行心肌灌注压力测试。在应力同位素注射后所需的等待期内，使用专用乳腺成像伽马相机系统进行 MBI。 MBI 检查由乳腺放射科医生解释，并对 MBI 阳性病例的近期乳房 X 光检查进行审查。
结果
在 322 名登记的女性中，313 名完成了 MBI，其中 5 名患有已知乳腺癌，2 名患有已知高风险良性乳腺病变，306 名无乳腺疾病症状但最近乳房 X 光检查呈阴性。分析仅限于 306 名没有已知乳腺疾病的患者。 306 例中有 22 例 MBI 呈阳性，召回率为 7.2%（95% 置信区间 [CI] 4.8-10.6]。MBI 检测到 4 种新癌症，导致补充诊断率为 13.1/1000 名筛查女性（95% CI 5.1-33.2）。每次异常 MBI 检查 (PPV(1)) 诊断出的癌症数量为 18%（4 例）。 22) (95% CI 7.3-38.5)，每次 MBI 提示活检 (PPV(3)) 诊断的人数为 44% (9 中的 4) (95% CI 18.9-73.3)。
结论
将 MBI 添加到临床指示的女性应激性心肌灌注成像研究中，可以提高新检测到的乳腺癌的诊断率，同时减少额外不必要检查的发生率。
BACKGROUND
Our objective was to explore the potential benefits of molecular breast imaging (MBI) as a screening technique in women undergoing stress myocardial perfusion studies.
METHODS
MBI was offered to women receiving Tc-99m sestamibi injection for myocardial perfusion stress testing. During the required waiting period after stress isotope injection, MBI was performed using a dedicated breast imaging gamma camera system. MBI examinations were interpreted by breast radiologists, with review of a recent mammogram in cases with positive MBI.
RESULTS
Of 322 women enrolled, 313 completed MBI, comprising 5 with known breast cancer, 2 with known high-risk benign breast lesions, and 306 who were asymptomatic for breast disease with a recent negative mammogram. Analysis was limited to the 306 patients with no known breast disease. MBI was positive in 22 of 306, giving a recall rate of 7.2% (95% confidence interval [CI] 4.8-10.6]. MBI detected 4 new cancers, resulting in a supplemental diagnostic yield of 13.1/1000 women screened (95% CI 5.1-33.2). The number of cancers diagnosed per abnormal MBI examinations (PPV(1)) was 18% (4 of 22) (95% CI 7.3-38.5), and the number diagnosed per MBI-prompted biopsies (PPV(3)) was 44% (4 of 9) (95% CI 18.9-73.3).
CONCLUSIONS
The addition of MBI to clinically indicated stress myocardial perfusion imaging studies in women results in a high diagnostic yield of newly detected breast cancers while generating a low rate of additional unnecessary workup.
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影响因子：
10.3
作者：
Buist, DSM;Porter, PL;White, E
通讯作者：
White, E
DOI：
10.1093/jnci/djh067
发表时间：
2004-02-04
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Gur, D;Sumkin, JH;Wallace, L
通讯作者：
Wallace, L
六（烷基异腈）锝-99m 复合物的非心脏应用。
DOI：
--
发表时间：
1990
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Piwnica-Worms,D;Holman,BL
通讯作者：
Holman,BL
一种新型 Tc-99m 标记心肌显像剂，六（叔丁基异腈）-锝(I) [Tc-99m TBI]：人体初步经验。
DOI：
--
发表时间：
1984
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Holman,BL;Jones,AG;Lister-James,J;Davison,A;Abrams,MJ;Kirshenbaum,JM;Tumeh,SS;English,RJ
通讯作者：
English,RJ