Intraocular pressure fluctuation and the risk of glaucomatous damage deterioration: a Meta-analysis
Intraocular pressure fluctuation and the risk of glaucomatous damage deterioration: a Meta-analysis
复制标题
DOI：
10.18240/ijo.2019.01.19
复制
发表时间：
2019-01-18
影响因子：
1.4
通讯作者：
Wei, Xin
中科院分区：
文献类型：
--
作者：
Guo, Zhen-Zhen;Chang, Karen;Wei, Xin
目的：为系统评价眼压波动性增加是否为开角型青光眼（OAG）进展的危险因素，从MEDLINE、EMBASE和CENTRAL数据库中检索与眼压波动性增加和青光眼进展相关的文献，并将其作为参考文献。根据纳入研究的异质性，采用固定或随机效应模型计算风险比（HR）。结果：纳入14项前瞻性研究中2637例OAG患者2211只眼的个体数据。所有研究均为纵向临床研究，随访期为3 - 8.5年。眼压波动与青光眼发病或进展之间的联合HR为1.23（95%CI 1.04-1.46，P=0.02），具有异质性（P
AIM: To systematically review whether the increased fluctuation of intraocular pressure (IOP) is a risk factor for open angle glaucoma (OAG) progression.METHODS: Scientific studies relevant to IOP fluctuation and glaucoma progression were retrieved from MEDLINE, EMBASE and CENTRAL databases, and were listed as references in this paper. The hazard ratio (HR) was calculated by using fixed or random-effects models according to the heterogeneity of included studies.RESULTS: Individual data for 2211 eyes of 2637 OAG patients in fourteen prospective studies were included in this Meta-analysis. All studies were longitudinal clinical studies with follow-up period ranging from 3 to 8.5y. The combined HR was 1.23 (95% CI 1.04-1.46, P=0.02) for the association between IOP fluctuation and glaucoma onset or progression with the evidence of heterogeneity (P