Effects of nitric oxide inhibition on systemic and renal hemodynamics in the hemorrhaged rat.
Effects of nitric oxide inhibition on systemic and renal hemodynamics in the hemorrhaged rat.
复制标题
一氧化氮抑制对出血大鼠全身和肾脏血流动力学的影响。
DOI：
10.1159/000174097
复制
发表时间：
1996
影响因子：
2.8
通讯作者：
Valeri,CR
中科院分区：
文献类型：
--
作者：
Lieberthal,W;Thompson,A;Valeri,CR
在正常血压、正常血容量大鼠和急性失血性低血压大鼠中比较了L-Name抑制一氧化氮（NO）的全身和肾脏血流动力学反应。正常血容量大鼠和老年肥胖大鼠的平均动脉血压升高。两组大鼠的体循环阻力均增加，但正常血压大鼠的增加幅度（104 ± 11%）大于高血压大鼠（64 ± 14%）。肾血管阻力正常组（189 ± 20%）较高血压组（102 ± 19%）明显增加（P < 0.05）。L-Name使正常血容量大鼠的肾小球滤过率明显降低（从3.0 ± 0.1 ml/min/300 g降至2.1 ± 0.1 ml/min/300 g），但使老龄大鼠的肾小球滤过率升高（从1.8 ± 0.2 ml/min/300 g增至2.5 ± 0.2 ml/min/300 g）。总之，L-Name诱导的血管阻力增加在出血后显著降低，表明NO的产生或可用性降低。然而，NO的生产继续在老龄大鼠，并大大有助于低血压和功能性肾功能不全与急性严重容量不足。
The systemic and renal hemodynamic responses to nitric oxide (NO) inhibition withL-Name were compared in both normotensive, normovolemic rats and in rats following acute hemorrhagic hypotension. The mean arterial blood pressure increased in normovolemic as well as in hemorrhaged, hypotensive rats. The systemic vascular resistance also increased in both groups, but the increase was greater in normotensive rats (104 ± 11%) than in hypotensive rats (64 ± 14%). The renal vascular resistance also increased more in normotensive rats (189 ± 20%) than in hypotensive rats (102 ± 19%; p < 0.05). The glomerular filtration rate was markedly reduced byL-Name in normovolemic rats (from 3.0 ± 0.1 to 2.1 ± 0.1 ml/min/300 g), but increased in hemorrhaged rats followingL-Name (from 1.8 ± 0.2 to 2.5 ± 0.2 ml/min/300 g). In summary, theL-Name-induced increase in vascular resistance is markedly reduced following hemorrhage, suggesting that NO production or availability is reduced. However, the NO production continues in the hemorrhaged rat and contributes substantially to the hypotension and functional renal insufficiency associated with acute severe volume depletion.