Dots-on-Plots: A Web Application to Analyze Stress-Strain Curves From Tensile Tests of Soft Tissue.
Dots-on-Plots: A Web Application to Analyze Stress-Strain Curves From Tensile Tests of Soft Tissue.
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Dots-on-Plots：用于分析软组织拉伸测试中的应力-应变曲线的 Web 应用程序。
DOI：
10.1115/1.4055593
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Lujan,TrevorJ
中科院分区：
文献类型：
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作者：
Nesbitt,DerekQ;Nelson,MirandaL;Shannon,KyleS;Lujan,TrevorJ
从应力-应变曲线计算拉伸力学性能是表征材料行为的基本步骤，但目前还没有标准化的方法来对软组织进行这些计算。为了解决这一不足，我们开发了一个免费的Web应用程序，称为Dots-on-Plots，它可以完全自动从应力-应变曲线计算拉伸机械性能。分析的力学特性包括四个关注点(过渡、屈服、极限和断裂)的强度、应变和能量，以及线弹性系数。Dot-on-Plot的用户可以上传多个文件、查看和下载结果以及调整阈值设置。这项研究确定了一个阈值设置，使计算过渡点时的误差最小，在该过渡点，应力-应变曲线从一个非线性的“脚趾”区域“过渡”到一个线性区域。使用最佳阈值(与线性区域拟合的应力偏差为2%)，Dot-on-Plots计算出20个人体半月板拉伸实验的转变应变值为0.049 ± 0.007，与已知的0.050 ± 0.006(通过有限元参数优化确定)的转变应变值几乎一致。利用一组模型生成的合成数据分析了计算的转变应变对各种应力-应变曲线形状的敏感性。这个免费的Web应用程序提供了一个方便可靠的工具，可以系统地提高生物医学研究小组的机械分析的速度、透明度和一致性。
The calculation of tensile mechanical properties from stress–strain curves is a fundamental step in characterizing material behavior, yet no standardized method exists to perform these calculations for soft tissue. To address this deficiency, we developed a free web application called Dots-on-Plots that fully automates the calculation of tensile mechanical properties from stress–strain curves. The analyzed mechanical properties include the strength, strain, and energy at four points of interest (transition, yield, ultimate, and rupture), and the linear modulus. Users of Dots-on-Plots can upload multiple files, view and download results, and adjust threshold settings. This study determined a threshold setting that minimized error when calculating the transition point, where the stress–strain curve “transitions” from a nonlinear “toe” region to a linear region. Using the optimal threshold (2% stress deviation from a linear region fit), Dots-on-Plots calculated the transition strains from twenty tensile experiments of human meniscus to be 0.049 ± 0.007, which nearly matched the known transition strain values of 0.050 ± 0.006 (determined using finite element parameter optimization). The sensitivity of the calculated transition strain to the shape of various stress–strain curves was analyzed using sets of model-generated synthetic data. This free web application offers a convenient and reliable tool to systematically enhance the speed, transparency, and consistency of mechanical analysis across biomedical research groups.