Vestibulo-ocular reflex tests may reflect unilateral Ménière disease progression: A cross-sectional study.
Vestibulo-ocular reflex tests may reflect unilateral Ménière disease progression: A cross-sectional study.
复制标题
前庭眼反射测试可反映单侧梅尼埃病进展横断面研究
DOI：
10.1097/md.0000000000023706
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发表时间：
2020-12-24
期刊：
影响因子：
1.6
通讯作者：
Liu B
中科院分区：
文献类型：
--
作者：
Zhou R;Leng Y;Liu B
前庭疾病可以表现出几种水平前庭反射（VOR）损伤的模式，可以通过热量测试和视频头脉冲测试（VHIT）检测到一些模式。这项研究的目的是调查热量响应的多样性及其在单侧MD患者中的相关因素。通过使用水平VOR测试的单侧MD的进展。
招募了98名单侧MD的患者，并接受了一系列音频评估，包括纯音调听力图，热量测试和水平VHIT。被定性地分为4种模式：模式I：正常的热量和VHIT响应；正常的反应；正常的热量和异常的反应：异常的热量反应。分析了模式/子图案和相关因素。
在35例（35.7％）中发现了模式，在57例中II（58.2％）和6个模式IV（6.1％）。年龄，电卵形和甘油测试持续时间与模式分布无关，同时与子图案分布保持关系在MD阶段有显着变化。
MD可以表现出几种水平VOR损害的模式，其中最常见的vHit热量响应是最常见的模式。前庭毛细胞受损。
Vestibular disorders can manifest several patterns of horizontal vestibulo-ocular reflex (VOR) impairment, which can be detected by caloric test and video head impulse test (vHIT). Several studies have examined the patterns of caloric-vHIT response in Ménière disease (MD). The purpose of this study was to investigate the diversity of caloric-vHIT response and its related factors in unilateral MD patients. We also explore the possibility of assessing the progression of unilateral MD by using the horizontal VOR tests. Ninety-eight patients with unilateral MD were enrolled and underwent a battery of audio-vestibular evaluations, including the pure tone audiogram, caloric test, and horizontal vHIT. Some patients received the electrocochleography and glycerol test. The combined results of caloric test and horizontal vHIT were categorized qualitatively into 4 patterns: Pattern I: normal caloric and vHIT responses; Pattern II: abnormal caloric and normal vHIT responses; Pattern III: normal caloric and abnormal vHIT response; and Pattern IV: abnormal caloric and vHIT responses. The abnormal caloric results were semi-quantitatively subdivided into sub-patterns as mild, moderate, and severe abnormality. The associations between these patterns/sub-patterns and related factors were analyzed. Pattern I was found in 35 cases (35.7%), Pattern II in 57 (58.2%), and Pattern IV in 6 (6.1%). No patient had Pattern III. No significant differences were found between the patterns/sub-pattern distribution and age, electrocochleography, and glycerol test results. Disease duration was not associated with the pattern distribution, while remained a relation with sub-pattern distribution. The pattern/sub-pattern distribution varied significantly across MD stages. The proportion of pattern II or pattern IV increased with the stage of unilateral MD. MD can manifest several patterns of horizontal VOR impairment, of which the impaired caloric response with normal vHIT is the most common pattern. With the progression of unilateral MD, the caloric-vHIT pattern tends to shift, which may reflect the deterioration of endolymphatic hydrops and vestibular hair cells impairments.