Object tracking in motion-blind flies
Object tracking in motion-blind flies
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DOI：
10.1038/nn.3386
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发表时间：
2013-06-01
影响因子：
25
通讯作者：
Borst, Alexander
中科院分区：
文献类型：
--
作者：
Bahl, Armin;Ammer, Georg;Borst, Alexander
一个物体的不同视觉特征，如它的位置和运动方向，是动物定向的重要元素，但提取它们的神经回路通常还不太清楚。我们在果蝇中分析了这个问题，重点是两个研究得很好的行为，称为视动反应和注视反应。在控制视动反应的神经回路中，柱状T4和T5细胞被认为是至关重要的。我们发现阻断T4和T5细胞导致视动反应的完全丧失。然而，这些苍蝇仍然能够固定一个黑色的酒吧，虽然在降低性能水平。进一步的分析表明，T4和T5细胞被阻止的苍蝇拥有一个完整的位置电路，该电路与运动电路并行实现; optomotor响应完全由运动电路控制，而固定响应由位置和运动电路支持。
Different visual features of an object, such as its position and direction of motion, are important elements for animal orientation, but the neural circuits extracting them are generally not well understood. We analyzed this problem in Drosophila, focusing on two well-studied behaviors known as optomotor response and fixation response. In the neural circuit controlling the optomotor response, columnar T4 and T5 cells are thought to be crucial. We found that blocking T4 and T5 cells resulted in a complete loss of the optomotor response. Nevertheless, these flies were still able to fixate a black bar, although at a reduced performance level. Further analysis revealed that flies in which T4 and T5 cells were blocked possess an intact position circuit that is implemented in parallel to the motion circuit; the optomotor response is exclusively controlled by the motion circuit, whereas the fixation response is supported by both the position and the motion circuit.