Oxytocin and bone status in men: analysis of the MINOS cohort
Oxytocin and bone status in men: analysis of the MINOS cohort
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DOI：
10.1007/s00198-015-3201-3
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发表时间：
2015-12-01
影响因子：
4
通讯作者：
Szulc, P.
中科院分区：
文献类型：
--
作者：
Breuil, V.;Fontas, E.;Szulc, P.
催产素是一种神经垂体激素，在动物研究和绝经后妇女中调节骨代谢。在男性中，催产素与骨密度，骨转换标志物，或普遍骨折，但弱负与事件脆性骨折需要进一步studies.Introduction我们以前表明，血清催产素（OT）水平与骨密度（BMD）和骨转换率在绝经后妇女。我们的研究的目的是评估之间的关系循环OT水平和骨骼statusinemen.Methods在552名男性年龄在50岁及以上的MINOS队列，我们测量血清OT水平。我们评估了血清OT水平与BMD的关系，（腰椎、股骨颈、全髋）、骨转换标志物（BTM）（血清I型前胶原N末端前肽（PINP）、骨特异性碱性磷酸酶结果在单因素分析中，血清OT水平与骨密度、骨钙素水平、骨或伴有普遍或偶发骨折。OT与体重指数（BMI）显著相关（r = 0.17，p < 0.001）、总的或生物可利用的17 β-雌二醇（分别为r = 0.09，p = 0.04和r = 0.20，p < 0.001）、游离睾酮（r = 0.17，p < 0.001）和瘦素（r = 0.16，p < 0.001）。多因素分析显示血清OT与BMD无显著相关性。校正年龄后，BMI、BMI/年龄交互作用、去年跌倒史、BMD、OT和骨折发生率均无相关性。相比之下，对普遍骨折进行额外调整的相同分析显示，OT与偶发骨折之间存在微弱的显著负相关，例如，校正股骨颈BMD后HR = 0.73，95%CI 0.55-0.99，p = 0.04。结论男性血清OT水平与BMD、骨转换率及骨折发生率无关。与骨折风险的弱负相关性需要进一步研究。
Oxytocin, a neurohypophysial hormone, regulates bone metabolism in animal studies and postmenopausal women. In men, oxytocin is not associated with bone mineral density, bone turnover markers, or prevalent fractures, but weakly negatively with incident fragility fracture requiring further studies.Introduction We previously showed that serum oxytocin (OT) level is associated with bone mineral density (BMD) and bone turnover rate in postmenopausal women. The aim of our study was to assess the relationship between circulating OT levels and bone status in men.Methods In 552 men aged 50 and older from the MINOS cohort, we measured serum levels of OT. We assessed the association of serum OT levels with BMD (lumbar, femoral neck, total hip), bone turnover markers (BTM) (serum N-terminal propeptide of type I procollagen (PINP), bone-specific alkaline phosphatase (bone ALP), and C-terminal telopeptide of type I collagen (CTX-I)) and fracture risk.Results In the univariate analysis, serum OT level was not associated with BMD at any site, BTM levels, or with prevalent or incident fracture. OT was significantly correlated with body mass index (BMI) (r = 0.17, p < 0.001), total or bioavalaible 17 beta-estradiol (r = 0.09, p = 0.04 and r = 0.20, p < 0.001, respectively), free testosterone (r = 0.17, p < 0.001), and leptin (r = 0.16, p < 0.001). Multivariate analysis did not show significant relationship between serum OT and BMD. After adjustment for age, BMI, interaction BMI/age, history of fall in the last year, and BMD, OT and prevalent fracture were not associated. By contrast, the same analysis with additional adjustment for prevalent fracture showed a weakly significant negative association between OT and incident fracture, e.g., after adjustment for femoral neck BMD, HR = 0.73, 95 %CI 0.55-0.99, p = 0.04.Conclusion In men, serum OT levels are not associated with BMD, bone turnover rate, or prevalent fractures. The weak negative relationship with fracture risk requires further studies.