Ablative fractional laser resurfacing for treatment of sclerosis and contractures in chronic graft-versus-host disease: A pilot study.
Ablative fractional laser resurfacing for treatment of sclerosis and contractures in chronic graft-versus-host disease: A pilot study.
复制标题
烧蚀点阵激光换肤治疗慢性移植物抗宿主病的硬化和挛缩：一项试点研究。
DOI：
10.1016/j.jaad.2019.07.084
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发表时间：
2020
影响因子：
13.8
通讯作者：
Sobanko,JosephF
中科院分区：
文献类型：
--
作者：
Micheletti,RobertG;Chansky,PeterB;Haun,PaulL;Seykora,JohnT;Dekerlegand,Jennifer;Sultan,LaithR;Schultz,SusanM;Sehgal,ChandraM;Sobanko,JosephF
Cutaneous sclerosis is a disabling complication of chronic graft-versus-host disease (cGVHD) that leads to joint contractures and reduced range of motion (ROM). Current therapies are limited by adverse effects and poor efficacy, and no systemic treatment successfully reverses cGVHD-induced sclerotic skin changes. 1 There is an urgent need for therapies to address the debilitating effects of cutaneous sclerosis in cGVHD.The ablative fractional CO2 laser remodels collagen and reduces fibrosis. It has been used for treatment of scars and contractures secondary to linear morphea, burns, and traumatic injury, conditions resembling the sclerosis of cGVHD. 2, 3 We evaluated the safety, tolerability, and efficacy of the ablative fractional CO2 laser for cGVHD-related sclerosis and joint contractures.
