Laser assisted topical 'biofilm' chemoprevention of oral cancer.
Laser assisted topical 'biofilm' chemoprevention of oral cancer.
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激光辅助局部“生物膜”化学预防口腔癌。
DOI：
10.1016/j.canlet.2004.05.009
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Shapshay,StanleyM
中科院分区：
文献类型：
--
作者：
Wang,Zhi;Polavaram,Raju;Gooey,John;Davis,LanceH;Shapshay,StanleyM
This study examines whether a combination of laser microvascular targeting, mucosal adhesive film (MAF) and retinoic acid (RA) techniques would improve the efficacy for oral cancer chemoprevention. The cheek pouches of 48 hamsters were painted with 7,12-dimethlbenz[a]nthrancene to produce premalignant lesions. There were four groups of 12 each: (1) control; (2) pulsed dye laser (PDL) treatment; (3) topical MAF/RA patch treatment; and (4) combined treatment of PDL and MAF/RA. The treatments were conducted for 27 days. Our findings indicate that this new combined treatment is safe and effective for oral cancer chemoprevention, and warrants further study.
