A CMOS Magnitude/Phase Measurement Chip for Impedance Spectroscopy
A CMOS Magnitude/Phase Measurement Chip for Impedance Spectroscopy
复制标题
DOI：
10.1109/jsen.2013.2251628
复制
发表时间：
2013-06-01
影响因子：
4.3
通讯作者：
Demosthenous, Andreas
中科院分区：
文献类型：
--
作者：
Kassanos, Panagiotis;Triantis, Iasonas F.;Demosthenous, Andreas
电阻抗的测量被用于大量的生物医学应用中。最常用的技术是同步解调，它提供阻抗的真实的和虚部。然而，在实践中，该方法需要在注入和监测阶段之间进行精细的校准和匹配。本文提出了一种替代方法，是复杂的实现集成实现。该电路采用0.35 μ m CMOS工艺制造，有源区面积为0.4 mm（2），+/- 2.5 V电源功耗约为21 mW。该芯片被用来测量在100 Hz至100 kHz的频率范围内的电极-组织界面的等效RC电路，表现出良好的相关性与理论结果。
The measurement of electrical impedance is used in a plethora of biomedical applications. The most common technique used is synchronous demodulation, which provides the real and imaginary parts of the impedance. However, in practice, the method requires elaborate calibration and matching between the injection and monitoring stages. This paper presents the integrated realization of an alternative method that is less intricate to implement. The circuit was fabricated in a 0.35-mu m CMOS technology, occupies an active area of 0.4 mm(2), and dissipates about 21 mW of power from +/- 2.5 V supplies. The chip was used to measure equivalent RC circuits of the electrode-tissue interface over the frequency range of 100 Hz to 100 kHz, showing good correlation with the theoretical results.