Relation between depression and circulating immune products in patients with advanced colorectal cancer
Relation between depression and circulating immune products in patients with advanced colorectal cancer
复制标题
DOI：
10.1177/014107689809100803
复制
发表时间：
1998-08-01
影响因子：
17.3
通讯作者：
Davies, M
中科院分区：
文献类型：
--
作者：
Allen-Mersh, TG;Glover, C;Davies, M
我们之前提出，结直肠肝转移可能产生“毒素”，降低生活质量（QoL）和生存率。在这项研究中，我们通过血清白细胞介素6 （IL6）、可溶性肿瘤坏死因子受体1 （sTNFr1）、可溶性白细胞介素2受体α (sIL2r α)或干扰素γ标记物neopterin水平的升高来评估此类转移患者的生活质量是否与免疫激活有关。测定43例患者血清il - 6、sTNFr1、sIL2r α、neopterin、碱性磷酸酶和癌胚胎抗原水平、肝转移量和QoL（医院焦虑和抑郁量表（HAD）、鹿特丹症状检查表（RSC）和疾病影响量表（SIP））。血清sIL2r α与HAD抑郁评分（r=0.66， P=0.0001）、RSC身体症状评分（r=0.46， P=0.0001）呈显著正相关
We have previously suggested that colorectal liver metastases might produce 'toxins' that reduce both quality of life (QoL) and survival. In this study we assessed whether QoL in patients with such metastases was related to immune activation, as determined by increased serum levels of interleukin 6 (IL6), soluble tumour necrosis factor receptor 1 (sTNFr1), soluble interleukin 2 receptor alpha (sIL2r alpha) or the interferon-gamma marker neopterin.Serum IL6, sTNFr1, sIL2r alpha, neopterin, alkaline phosphatase and carcinoembryonic antigen levels, liver metastasis volume, and QoL (Hospital Anxiety and Depression [HAD] scale, Rotterdam Symptom Checklist [RSC], and Sickness Impact Profile [SIP]) were measured in 43 patients. There were significant positive correlations between serum sIL2r alpha and HAD depression score (r=0.66, P=0.0001), RSC physical symptom score (r=0.46, P