Correlation of EGFR Mutation Status With Predominant Histologic Subtype of Adenocarcinoma According to the New Lung Adenocarcinoma Classification of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society
Correlation of EGFR Mutation Status With Predominant Histologic Subtype of Adenocarcinoma According to the New Lung Adenocarcinoma Classification of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society
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DOI：
10.5858/arpa.2013-0376-oa
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发表时间：
2014-10-01
影响因子：
4.6
通讯作者：
Raparia, Kirtee
中科院分区：
文献类型：
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作者：
Villa, Celina;Cagle, Philip T.;Raparia, Kirtee
背景。-表皮生长因子受体（EGFR）突变已被确定为非小细胞肺癌中EGFR酪氨酸激酶抑制剂反应的预测因子。根据新的国际肺癌研究协会（IASLC）/美国胸科学会（ATS）/欧洲呼吸学会（ERS）分类，研究EGFR突变状态与腺癌组织学亚型的关系。我们在2008年至2011年诊断的200例连续肺腺癌切除标本中筛查EGFR突变。在200例肺腺癌中，41例（20.5%）发现EGFR突变。EGFR突变组的平均年龄为64.8岁，该组由78%的女性和22%的男性组成。大多数EGFR阳性肺癌患者从不吸烟（51%），而EGFR阴性肺癌患者为8%（P
Context.-Epidermal growth factor receptor (EGFR) mutations have been identified as predictors of response to EGFR tyrosine kinase inhibitors in non-small cell lung cancer.Objective.-To investigate the relationship of EGFR mutation status to the histologic subtype of adenocarcinoma according to the new International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification.Design.-We screened EGFR mutation in 200 consecutive lung adenocarcinoma resection specimens diagnosed between 2008 and 2011.Results.-Among 200 lung adenocarcinomas, EGFR mutations were identified in 41 tumors (20.5%). The mean age in the EGFR-mutant group was 64.8 years and this group consisted of 78% females and 22% males. Most patients with EGFR-positive lung cancers were never-smokers (51%) as compared to 8% with EGFR-negative cancers (P