Electroencephalographic and perceptual asymmetry differences between responders and nonresponders to an SSRI antidepressant
Electroencephalographic and perceptual asymmetry differences between responders and nonresponders to an SSRI antidepressant
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DOI：
10.1016/s0006-3223(00)01016-7
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发表时间：
2001-03-01
影响因子：
10.6
通讯作者：
Quitkin, FM
中科院分区：
文献类型：
--
作者：
Bruder, GE;Stewart, JW;Quitkin, FM
背景：最近的报道表明脑电图和双耳分听测量作为抗抑郁药反应的预测指标的价值。本研究探讨了脑电图α不对称性和知觉不对称性的双耳两分测量作为氟西汀（百忧解）治疗12周临床反应预测因子的可能性。在治疗前阶段，对抑郁症门诊患者进行了评估（睁眼和闭眼）和用单词或复杂音调刺激的双耳分听。氟西汀应答者（n = 34）与无应答者（n = 19）在对双耳两分刺激的左半球处理优于右半球处理方面存在差异。他们在休息时的脑电图α不对称性也不同，特别是在眼睛睁开的情况下。无应答者显示α不对称性，表明右半球的整体激活程度高于左半球，而应答者则没有。半球的不对称性和治疗反应之间的关系与性别相互作用，抑郁症的妇女，但不是mentions.Conclusions明显：结果是一致的假设，一个特征倾向于更大的左半球比右半球激活与氟西汀的有利反应，而相反的半球不对称性预测不良反应。生物精神病学2001; 49：416-425（C）2001生物精神病学学会。
Background: Recent reports suggest the value of electroencephalographic and dichotic listening measures as predictors of response to antidepressants. This study examines the potential of electroencephalographic alpha asymmetry and dichotic measures of perceptual assymmetry as predictors of clinical response to 12 weeks of treatment with fluoxetine (Prozac),Methods: Resting electroencephalography (eyes open and eyes closed) and dichotic listening with word or complex tone stimuli were assessed in depressed outpatients during a pretreatment period.Results: Fluoxetine responders (n = 34) differed from nonresponders (n = 19) in favoring left over right hemisphere processing of dichotic stimuli. They also differed in their resting electroencephalographic alpha asymmetry, particularly, in the eyes open condition. Nonresponders showed an alpha asymmetry indicative of overall greater activation of the right hemisphere than the left, whereas responders did not. The relationship between hemispheric asymmetry and treatment response interacted with gender, being evident among depressed women but not men.Conclusions: The results are consistent with the hypothesis that a characteristic tendency toward greater left than right hemisphere activation is associated with favorable response to fluoxetine, whereas the opposite hemispheric asymmetry predicts poor response. Biol Psychiatry 2001; 49:416-425 (C) 2001 Society of Biological Psychiatry.