The duration of human ocular Chlamydia trachomatis infection is age dependent
The duration of human ocular Chlamydia trachomatis infection is age dependent
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DOI：
10.1017/s0950268899003076
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发表时间：
1999-12-01
影响因子：
4.2
通讯作者：
Mabey, D
中科院分区：
文献类型：
--
作者：
Bailey, R;Duong, T;Mabey, D
我们研究了年龄和患病率之间的关系，持续时间和发病率的临床和实验室证据的眼沙眼衣原体感染的冈比亚受试者队列检查，每两周一次，为期6个月。疾病和感染的持续时间，估计分层生存分析，比例风险回归和威布尔模型，是显着的年龄依赖性。13.2岁受试者的估计中位病程为13.2周，15岁及以上受试者为1.7周。多次感染和缺失观察结果的调整并未改变这一趋势。随着年龄的增长，疾病的累积发病率降低了三倍。更快的疾病消退是降低活动性沙眼和眼衣原体患病率的主要原因。沙眼感染与年龄有关;发病率降低程度较小。这种年龄依赖性的解决方案可能会受到适应性细胞免疫机制的影响。在疫苗设计中应适当强调自然免疫机制。
We studied the relationship between age and prevalence, duration and incidence of clinical and laboratory evidence of ocular Chlamydia trachomatis infection in a cohort of Gambian subjects examined bi-weekly for 6 months. The duration of disease and infection, estimated by stratified survival analysis, proportional hazards regression and Weibull modelling, was markedly age-dependent. The estimated median duration of disease was 13 2 weeks in 13.2-year-old subjects and 1.7 weeks in those age 15 and over. Adjustment for multiple infections, and for missing observations did not alter this trend. The cumulative incidence rate of disease was reduced threefold with age. More rapid disease resolution is the main source of reduction in prevalence of active trachoma and ocular C. trachomatis infection with age; disease incidence was reduced to a lesser extent. This age-dependent resolution may be effected by adaptive cellular immune mechanisms. Mechanisms responsible for natural immunity should receive appropriate emphasis in vaccine design.