Quantitative proton radiation therapy dosimetry using the storage phosphor europium-doped potassium chloride
Quantitative proton radiation therapy dosimetry using the storage phosphor europium-doped potassium chloride
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DOI：
10.1002/mp.14423
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发表时间：
2020-08-16
期刊：
影响因子：
3.8
通讯作者：
Li, H. Harold
中科院分区：
文献类型：
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作者：
Setianegara, Jufri;Mazur, Thomas R.;Li, H. Harold
目的：为了（a）表征用于定量质子剂量学的存储磷光体掺铕氯化钾的基本光学和剂量学性质，和（B）研究其剂量辐射响应是否可以由分析辐射输运模型描述，方法：内部制造直径为6 mm和厚度为1 mm的圆柱形KCl：Eu（2+）剂量计。使用Mevion S250被动散射质子治疗系统和Varian Clinac iX直线加速器照射剂量计。测量了质子和光子辐照下的光激励发光（PSL）发射光谱、激发光谱和发光寿命。剂量学性质，包括辐射硬度，剂量线性，信号稳定性，剂量率灵敏度，和能量依赖性进行了研究，使用实验室光学阅读器照射后。剂量计使用的物理量，包括在存储磷光体和水的质量阻止功率为一个给定的质子beam，和质量能量吸收系数和质量阻止功率在检测器和水为一个给定的photonbeam.Results：KCl：Eu（2+）表现出的光发射和刺激峰分别在421和560 nm，质子和光子照射，使postirradiation读出使用可见光源，同时检测PSL使用光电倍增管。KCl：Eu（2+）在0 ~ 8戈伊吸收剂量-水范围内呈线性响应，动态范围可达60戈伊，剂量率无关性为83 ~ 500 MU/min，PSL寿命为
Purpose: To (a) characterize the fundamental optical and dosimetric properties of the storage phosphor europium-doped potassium chloride for quantitative proton dosimetry, and (b) investigate if its dose radiation response can be described by an analytic radiation transport model.Methods: Cylindrical KCl:Eu(2+)dosimeters with dimensions of 6 mm diameter and 1 mm thickness were fabricated in-house. The dosimeters were irradiated using both a Mevion S250 passive scattering proton therapy system and a Varian Clinac iX linear accelerator. Photostimulated luminescence (PSL) emission spectra, excitation spectra, and luminescence lifetimes were measured for both proton and photon irradiations. Dosimetric properties including radiation hardness, dose linearity, signal stabilization, dose rate sensitivity, and energy dependence were studied using a laboratory optical reader after irradiations. The dosimeters were modeled using physical quantities including mass stopping powers in the storage phosphor and water for a given proton beam, and mass energy absorption coefficients and massing stopping powers in detector and water for a given photon beam.Results: KCl:Eu(2+)exhibited optical emission and stimulation peaks at 421 and 560 nm, respectively, for both proton and photon irradiations, enabling postirradiation readouts using a visible light source while detecting the PSL using a photomultiplier tube. KCl:Eu(2+)showed a linear response from 0 to 8 Gy absorbed dose-to-water, a large dynamic range up to 60 Gy, dose-rate independence measured from 83 to 500 MU/min, and a PSL lifetime of