Anemia in experimental protein deficiency in the rhesus monkey with special reference to iron metabolism.
Anemia in experimental protein deficiency in the rhesus monkey with special reference to iron metabolism.
复制标题
恒河猴实验性蛋白质缺乏症贫血，特别是铁代谢。
DOI：
10.1182/blood.v26.4.421.421
复制
发表时间：
1965
期刊：
影响因子：
20.3
通讯作者：
V. Ramalingaswami
中科院分区：
文献类型：
--
作者：
S. Sood;M. Deo;V. Ramalingaswami
1.本文对恒河猴蛋白质缺乏性贫血进行了研究。2.在17只恒河猴中诱导蛋白质缺乏。七只动物，给予富含蛋白质的饮食，作为对照。除了蛋白质外，两组的饮食在所有方面都是相同的。所有动物均采用管饲，以确保摄入足够的热量。红细胞压积，血红蛋白，红细胞计数，血清铁，血清铁结合力，血浆铁耐受曲线，铁吸收使用Fe 59粪便回收法进行了研究之前和实验的间隔在缺乏和对照组。蛋白质缺乏的猴子持续发展为中度的正红细胞正色素性贫血。在所有缺乏的动物中观察到血清铁结合力、总蛋白和白蛋白的显著下降，而γ球蛋白升高。还观察到血清铁的显著和可比下降。Fe ~（59）吸收降低，血浆铁耐受曲线变平。两个缺陷的动物，再喂高蛋白饮食，显示逆转所有这些变化。对照组动物未显示任何这些变化。贫血和铁吸收减少的机制中观察到的蛋白质缺乏的动物和这些发现的相关性在夸希奥科进行了讨论。
1. This investigation deals with a study of the anemia of protein deficiency in Rhesus monkeys. 2. Protein deficiency was induced in 17 rhesus monkeys. Seven animals, given a protein-rich diet, served as controls. The diets of both the groups were identical in all respects, except protein. All animals were tube-fed to ensure adequate caloric intake. Hematocrit, hemoglobin, erythroctye count, serum iron, serum iron binding capacity, plasma iron tolerance curves, and iron absorption using the Fe59 fecal recovery method were studied before and at intervals of the experiment in both deficient and control groups. Protein-deficient monkeys consistently developed normocytic normochromic anemia of moderate severity. A striking fall in serum iron binding capacity, total proteins and albumin with a rise in gamma globulin was observed in all deficient animals. A significant and comparable fall in serum iron was also observed. The Fe59 absorption was depressed and there was flattening of plasma iron tolerance curves. Two deficient animals, refed a high protein diet, showed reversal of all these changes. The control animals did not show any of these changes. The mechanism of anemia and decreased iron absorption observed in the protein-deficient animals and the relevance of these findings to those in Kwashiorkor are discussed.