Liver fibrosis assessed with transient elastography is an independent risk factor for ischemic stroke
Liver fibrosis assessed with transient elastography is an independent risk factor for ischemic stroke
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DOI：
10.1016/j.atherosclerosis.2017.02.005
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发表时间：
2017-05-01
期刊：
影响因子：
5.3
通讯作者：
Kim, Young Dae
中科院分区：
文献类型：
--
作者：
Kim, Seung Up;Song, Dongbeom;Kim, Young Dae
背景和目的：肝纤维化与缺血性卒中发生之间的关系尚不清楚。我们调查了短暂弹性成像（TE）评估的肝纤维化与缺血性stroke.Methods风险之间的相关性：2013年4月至2014年8月，急性缺血性卒中患者和接受健康检查的受试者被纳入研究。所有参与者的肝纤维化负荷均采用TE进行评估。结果：缺血性脑卒中患者295例（脑卒中组），健康体检者1942例（对照组）。脑卒中组的TE平均肝硬度（LS）（5.6 vs. 4.1 kPa）和显著纤维化（>8 kPa）的比例（9.2% vs. 1.8%）显著高于对照组（均为P
Background and aims: The relationship between liver fibrosis and the occurrence of ischemic stroke is unknown. We investigated the correlation between liver fibrosis assessed with transient elastography (TE) and the risk of ischemic stroke.Methods: Between April 2013 and August 2014, patients with acute ischemic stroke and subjects who underwent a health check-up were included in the study. Liver fibrotic burden was assessed with TE in all participants. The degree of liver fibrosis was compared between groups by using various multiple logistic regression models and propensity-score matched analyses.Results: Two hundred ninety-five patients with ischemic stroke (stroke group) and 1942 subjects with health check-up (control group) were included. The mean liver stiffness (LS) on TE (5.6 vs. 4.1 kPa) and the proportion of significant fibrosis (>8 kPa) (9.2% vs. 1.8%) were significantly higher in the stroke than in the control group (all p