ANXIOGENIC PROPERTIES OF YOHIMBINE .1. BEHAVIORAL, PHYSIOLOGICAL AND BIOCHEMICAL MEASURES
ANXIOGENIC PROPERTIES OF YOHIMBINE .1. BEHAVIORAL, PHYSIOLOGICAL AND BIOCHEMICAL MEASURES
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DOI：
10.1007/bf02191958
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发表时间：
1992-07-01
影响因子：
4.7
通讯作者：
BREIER, A
中科院分区：
文献类型：
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作者：
ALBUS, M;ZAHN, TP;BREIER, A
育亨宾是一种特殊的α -2受体拮抗剂，通过口服20毫克育亨宾给8名接受安慰剂治疗的恐慌患者，7名接受阿普唑仑治疗的恐慌患者和12名对照患者，研究了育亨宾的焦虑效应，采用双盲随机设计，指示最小化经历恐慌发作的预期和另外两种结构化情况。与对照组相比，育亨宾在恐慌患者的焦虑和恐慌评分、去甲肾上腺素分泌、最大心率和高心率变异性以及皮肤温度方面的增加更为明显。然而，可能是由于教学设置和实验设计，使患者从不愉快的身体感觉中分心，没有观察到恐慌发作。
The anxiogenic effects of yohimbine, a specific alpha-2-receptor antagonist were examined by administering 20 mg yohimbine orally to 8 panic patients on placebo treatment, 7 panic patients on alprazolam treatment and 12 controls using a double-blind randomized design, instructions that minimized the expectancy of experiencing a panic attack and two additional structured situations. Yohimbine induced more pronounced increases in anxiety and panicky ratings, norepinephrine secretion, maximum heart rate and high heart rate variability and decreases in skin temperature in panic patients compared with controls. However, possibly owing to an instructional set and experimental design that distracted patients from unpleasant bodily sensations no panic attacks were observed.