Distinct Nausea Profiles Are Associated With Gastrointestinal Symptoms in Oncology Patients Receiving Chemotherapy.
Distinct Nausea Profiles Are Associated With Gastrointestinal Symptoms in Oncology Patients Receiving Chemotherapy.
复制标题
接受化疗的肿瘤患者的不同恶心特征与胃肠道症状相关。
DOI：
10.1097/ncc.0000000000001076
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发表时间：
2023
期刊：
影响因子：
2.6
通讯作者：
Miaskowski,Christine
中科院分区：
文献类型：
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作者：
Singh,Komal;Pituch,Keenan;Zhu,Qiyun;Gu,Haiwei;Ernst,Brenda;Tofthagen,Cindy;Brewer,Melanie;Kober,KordM;Cooper,BruceA;Paul,StevenM;Conley,YvetteP;Hammer,Marilyn;Levine,JonD;Miaskowski,Christine
背景48%的化疗患者会发生化疗诱发的恶心（CIN），这是患者报告的最严重的衰弱症状之一。本研究的目的是确定具有不同CIN特征的患者亚组，并确定这些亚组在人口统计学和临床特征、CIN的严重程度、频率和痛苦方面的差异。方法1343例患者在2个化疗周期内完成6次人口学调查表和记忆症状评估量表。潜在类别分析用于识别具有不同CIN特征的患者亚组。这些亚组之间的差异进行了评估，使用参数和非参数statistics.Results4个不同的CIN配置文件确定：无（40.8%），增加，减少（21.5%），减少（8.9%），高（28.8%）。与无类别相比，高类别的患者更年轻，家庭年收入较低，有照顾孩子的责任，Karnofsky体能状态评分较低，自我管理的合并症问卷评分较高，更有可能接受14天周期的化疗和高致吐化疗方案。此外，在高级别的患者报告口干，感觉腹胀，腹泻，食欲不振，腹部绞痛，吞咽困难，口腔溃疡，体重减轻，并在食物的味道tastes.ConclusionsThat的方式改变发生率高，60%的患者报告中度至高度CIN发生率证实，这种未缓解的症状是一个重要的临床问题。
BackgroundUnrelieved chemotherapy-induced nausea (CIN) occurs 48% of patients undergoing chemotherapy and is one of the most debilitating symptoms that patients report.ObjectiveThe aims of this study were to identify subgroups of patients with distinct CIN profiles and determine how these subgroups differed on demographic and clinical characteristics; severity, frequency, and distress of CIN; and the co-occurrence of common gastrointestinal symptoms.MethodsPatients (n= 1343) completed demographic questionnaire and Memorial Symptom Assessment Scale 6 times over 2 cycles of chemotherapy. Latent class analysis was used to identify subgroups of patients with distinct CIN profiles. Differences among these subgroups were evaluated using parametric and nonparametric statistics.ResultsFour distinct CIN profiles were identified: none (40.8%), increasing-decreasing (21.5%), decreasing (8.9%), and high (28.8%). Compared with the none class, patients in the high class were younger, had a lower annual household income, had child care responsibilities, had a lower Karnofsky Performance Status score and a higher Self-administered Comorbidity Questionnaire score, and were more likely to have received chemotherapy on a 14-day cycle and a highly emetogenic chemotherapy regimen. In addition, patients in the high class reported high occurrence rates for dry mouth, feeling bloated, diarrhea, lack of appetite, abdominal cramps, difficulty swallowing, mouth sores, weight loss, and change in the way food tastes.ConclusionsThat 60% of the patients reported moderate to high CIN occurrence rates confirms that this unrelieved symptom is a significant clinical problem.