Tissue RNFT2 Expression Levels Are Associated With Peritoneal Recurrence and Poor Prognosis in Gastric Cancer
Tissue RNFT2 Expression Levels Are Associated With Peritoneal Recurrence and Poor Prognosis in Gastric Cancer
复制标题
DOI：
10.21873/anticanres.14812
复制
发表时间：
2021-02-01
影响因子：
2
通讯作者：
Kodera, Yasuhiro
中科院分区：
文献类型：
--
作者：
Sasahara, Masahiro;Kanda, Mitsuro;Kodera, Yasuhiro
背景/目的：进展期胃癌根治性切除术后常出现复发，预后不良。在本研究中，我们确定了一个预测胃癌根治性切除后复发和预后的候选生物标志物。材料和方法：对转移性胃癌患者手术切除的癌组织进行转录组分析，以确定原发组织和转移组织中表达上调的基因。结果：环指蛋白2(RNFT2)在胃癌原发灶和转移灶组织中的表达明显高于非癌组织。RNFT2在胃癌细胞系中的表达与EMT相关分子GSC、MMP9和RAC1呈正相关。RNFT2高表达组术后总生存期显著缩短。RNFT2高表达组腹膜复发率明显高于对照组。结论：RNFT2mRNA表达可预测腹膜复发，是胃癌根治性切除术后潜在的预后生物标志物。
Background/Aim: Disease recurrence is frequently observed after curative resection of advanced gastric cancer resulting in a poor prognosis. In the present study, we identified a candidate biomarker to predict recurrence and prognosis after curative resection of gastric cancer. Materials and Methods: A transcriptome analysis was conducted using surgically resected cancerous tissue from patients with metastatic gastric cancer to identify genes that are upregulated in primary and metastatic tissues. Results: Ring finger protein, transmembrane 2 (RNFT2) mRNA expression was upregulated in primary gastric cancer tissues and metastases compared with non-cancerous tissues. RNFT2 expression in gastric cancer cell lines was positively correlated with the EMT-related molecules GSC, MMP9, and RAC1. The RNFT2 high expression group exhibited a significantly shorter postoperative overall survival. Peritoneal recurrence was significantly higher in the RNFT2 high expression group. Conclusion: RNFT2 mRNA expression predicts peritoneal recurrence and is a potential prognostic biomarker for gastric cancer following curative gastrectomy.