Mechanisms of adaptation in a predator-prey arms race: TTX-resistant sodium channels
Mechanisms of adaptation in a predator-prey arms race: TTX-resistant sodium channels
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DOI：
10.1126/science.1074310
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发表时间：
2002-08-23
期刊：
影响因子：
56.9
通讯作者：
Brodie, ED
中科院分区：
文献类型：
--
作者：
Geffeney, S;Brodie, ED;Brodie, ED
种群的束带蛇Thamnophis sirtalis进化地理可变的河豚毒素（TTX）在一个共同进化的军备竞赛与他们的有毒猎物，蝾螈属Taricha。在这里，我们确定了一个生理机制，TTX耐钠通道在骨骼肌中的表达，负责适应性多样化的整个动物的阻力。在TTX存在下，骨骼肌纤维功能的个体和群体差异与TTX抗性的整体动物测量密切相关。在一个基本的生理功能，负责种群之间的适应性差异的个体变异的证明是一个步骤，连接的选择性后果的共同进化的相互作用的地理和系统发育的多样性模式。
Populations of the garter snake Thamnophis sirtalis have evolved geographically variable resistance to tetrodotoxin ( TTX) in a coevolutionary arms race with their toxic prey, newts of the genus Taricha. Here, we identify a physiological mechanism, the expression of TTX-resistant sodium channels in skeletal muscle, responsible for adaptive diversification in whole-animal resistance. Both individual and population differences in the ability of skeletal muscle fibers to function in the presence of TTX correlate closely with whole-animal measures of TTX resistance. Demonstration of individual variation in an essential physiological function responsible for the adaptive differences among populations is a step toward linking the selective consequences of coevolutionary interactions to geographic and phylogenetic patterns of diversity.