Chemokines at large: In-vivo mechanisms of their transport, presentation and clearance
Chemokines at large: In-vivo mechanisms of their transport, presentation and clearance
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DOI：
10.1160/th07-02-0105
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发表时间：
2007-05-01
影响因子：
6.7
通讯作者：
Rot, Antal
中科院分区：
文献类型：
--
作者：
Colditz, Ian G.;Schneider, Martin A.;Rot, Antal
令人信服的证据暗示趋化因子在诱导白细胞从血液迁移到组织。这可以说是趋化因子最基本的作用是通过触发白细胞表面同源的经典g蛋白偶联趋化因子受体来完成的。在体外，这些受体介导白细胞迁移；然而，趋化因子诱导迁移的机制在体内和体外环境中有所不同。白细胞从血液中排出很大程度上受到血流动力学条件的影响，需要内皮细胞的充分配合。趋化因子在体内“原生栖息地”中的行为受其与几种辅助分子的相互作用控制，这些辅助分子影响趋化因子的固定、运输、清除和降解，从而决定其作用的位置和持续时间。在这里，我们讨论了趋化因子体内作用的特点，趋化因子与受体和辅助分子（包括拦截剂、糖胺聚糖和酶）相互作用的机制，并说明了这些相互作用如何影响趋化因子体内活性的结果。
Compelling evidence implicates chemokines in the induction of leukocyte emigration from blood into tissues.This arguably most fundamental effect of chemokines is accomplished by triggering cognate classical G-protein-coupled chemokine receptors on the leukocyte surface. In vitro,these same receptors mediate leukocyte migration; however, the mechanisms of chemokine-induced migration differ between in-vivo and in-vitro settings. Leukocyte egress from blood is greatly influenced by haemodynamic conditions and requires full cooperation of endothelial cells.The behaviour of chemokines in their "native habitat" in vivo is controlled by their interaction with several accessory molecules which influence immobilisation, transport, clearance and degradation of chemokines and thereby determine the sites and duration of their action. Here we discuss peculiarities of the in-vivo actions of chemokines,the mechanisms of chemokine interaction with receptors and auxiliary molecules including interceptors, glycosaminoglycans and enzymes and illustrate how these interactions influence the outcome of chemokine activities in vivo.