Contributions of dopaminergic signaling to timing accuracy and precision
Contributions of dopaminergic signaling to timing accuracy and precision
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DOI：
10.1016/j.cobeha.2016.02.013
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发表时间：
2016-04-01
影响因子：
5
通讯作者：
Cheng, Ruey-Kuang
中科院分区：
文献类型：
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作者：
Agostino, Patricia V.;Cheng, Ruey-Kuang
现有证据表明，间隔计时，即在百分之一毫秒到分钟范围内处理时间信息，可以通过多巴胺能-谷氨酸能途径招募广泛的大脑区域，例如皮质纹状体回路。在这篇综述中，我们总结了关于间隔时间的神经生物学基础的最新发现，特别关注时间信息的多巴胺能调节。间隔计时的两个属性——准确度和精确度——用于检查多巴胺能信号操纵的最新结果以及时间处理中产生的扭曲。
Existing evidence suggests that interval timing, processing of temporal information in the hundredth of milliseconds-to-minutes range, recruits broad brain regions such as corticostriatal circuits via dopaminergic-glutamatergic pathways. In this review, we summarize recent findings on the neurobiological basis of interval timing with a special focus on dopaminergic modulations of temporal information. Two properties of interval timing-accuracy and precision-are used to examine recent results from manipulations of dopaminergic signaling and the resulting distortions in temporal processing.