Positive Maternal C-Reactive Protein Predicts Neonatal Sepsis
Positive Maternal C-Reactive Protein Predicts Neonatal Sepsis
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DOI：
10.3349/ymj.2014.55.1.113
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发表时间：
2014-01-01
影响因子：
2.4
通讯作者：
Lee, Chul
中科院分区：
文献类型：
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作者：
Jeon, Ji Hyun;Namgung, Ran;Lee, Chul
目的：评价母体炎症标志物c反应蛋白（CRP）在预测早发型新生儿脓毒症（出生后72小时内发生的脓毒症）中的诊断作用。材料与方法：126例低出生体重新生儿（孕32 +/- 3.2周，出生体重1887 +/- 623 g）及其母亲。将新生儿分为确诊（血培养阳性）和疑似（血培养阴性但有3个以上临床异常体征）脓毒症组（51例）和对照组（75例）。将母亲分为CRP阳性bb0 = 1.22 mg/dL （n=48）和CRP阴性bb0 = 1.22 mg/dL，预测新生儿败血症的敏感性为71%，特异性为84%。CRP阳性组新生儿败血症发生率高于CRP阴性组(71% vs. 29%, p
Purpose: To evaluate the diagnostic performance of maternal inflammatory marker: C-reactive protein (CRP) in predicting early onset neonatal sepsis (that occurring within 72 hours after birth). Materials and Methods: 126 low birth weight newborns (gestation 32 +/- 3.2 wk, birth weight 1887 +/- 623 g) and their mothers were included. Neonates were divided into sepsis group (n=51) including both proven (positive blood culture) and suspected (negative blood culture but with more than 3 abnormal clinical signs), and controls (n=75). Mothers were subgrouped into CRP positive >= 1.22 mg/dL (n=48) and CRP negative 1.22 mg/dL) had sensitivity 71% and specificity 84% for predicting neonatal sepsis. Maternal CRP positive group had more neonatal sepsis than CRP negative group (71% vs. 29%, p