SARS-CoV2 and pregnancy: An invisible enemy?
SARS-CoV2 and pregnancy: An invisible enemy?
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DOI：
10.1111/aji.13308
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发表时间：
2020-08-01
影响因子：
3.6
通讯作者：
Mysorekar, Indira U.
中科院分区：
文献类型：
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作者：
Verma, Sonam;Carter, Ebony B.;Mysorekar, Indira U.
冠状病毒病2019或COVID-19是由冠状病毒家族成员SARS-CoV-2引起的新出现的病毒性疾病。自2019年12月出现以来，它已在全球迅速造成近50万人死亡。关于COVID-19对妊娠影响的数据有限。在这里，我们回顾了SARS-COV -2检测阳性妇女的胎盘病理结果，以及与相关和高致病性冠状病毒（即严重急性呼吸综合征（SARS-COV）和中东呼吸综合征（MERS））相关的妊娠结局信息。我们介绍了妊娠期COVID-19的免疫炎症相关因素，并综述了肾素血管紧张素系统在妊娠期COVID-19发病机制中的作用。进一步了解胎盘中SARS-CoV-2的发病机制将为COVID-19孕妇的潜在治疗干预提供重要见解。
Coronavirus disease 2019 or COVID-19 is an emerging viral disease caused by a member of the betacoronavirus family, SARS-CoV-2. Since its' emergence in December 2019, it has rapidly caused close to half a million fatalities globally. Data regarding the impact of COVID-19 on pregnancy are limited. Here, we review pathological findings in placentas from women who tested positive for SARS-CoV-2 as well as information on pregnancy outcomes associated with related and highly pathogenic coronaviruses (ie, severe acute respiratory syndrome (SARS-COV) and the Middle East respiratory syndrome, MERS). We present immune-inflammatory correlates of COVID-19 in pregnancy and review the role of the Renin Angiotensin System in the pathogenesis of COVID-19 in pregnancy. Greater understanding of the pathogenesis of SARS-CoV-2 in the placenta will yield important insight into potential therapeutic interventions for pregnant women with COVID-19.