Decreased recovery of CD4 lymphocytes in older HIV-infected patients beginning highly active antiretroviral therapy
Decreased recovery of CD4 lymphocytes in older HIV-infected patients beginning highly active antiretroviral therapy
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DOI：
10.1097/00002030-200108170-00017
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发表时间：
2001-08-17
期刊：
影响因子：
3.8
通讯作者：
Alkasspooles, S
中科院分区：
文献类型：
--
作者：
Goetz, MB;Boscardin, WJ;Alkasspooles, S
在病毒学应答者中，55岁及以上患者在接受高效抗逆转录病毒治疗（HAART） 3、9、15和18个月后CD4计数减去基线（AUCMB）曲线下面积较小（P < 0.05）。很少有老年人达到50、100或超过150个CD4细胞/人。随机二次时间过程模型估计，在HAART治疗后的前12个月内，每增加10年的年龄，AUCMB每年减少35个细胞（P < 0.005）。
Among virological responders, the area under the curve of the CD4 count minus baseline (AUCMB) after 3, 9, 15 and 18 months of highly active antiretroviral therapy (HAART) was less in individuals 55 years or older (P < 0.05). Fewer older individuals achieved increases of 50, 100, or over 150 CD4 cells/mul. A random quadratic time course model estimated that the AUCMB decreased 35 cells/year for each 10 years of additional age during the first 12 months after HAART (P < 0.005).