Diagnosis of Thyroid Nodules: Use of Fine-Needle Aspiration and Needle Biopsy
Diagnosis of Thyroid Nodules: Use of Fine-Needle Aspiration and Needle Biopsy
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甲状腺结节的诊断：细针抽吸和针吸活检的使用
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
S. Kini
中科院分区：
文献类型：
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作者：
J. Miller;J. Hamburger;S. Kini
分别通过细针和大针活检获得的细胞学和组织学标本评价了455个甲状腺结节的诊断准确性，并与先前通过临床方法评价的1，094个结节的诊断准确性进行了比较。使用细胞组织学数据使疑似癌症患者的人数减少了一半，需要观察的患者人数增加了一倍。高、中度癌风险患者手术时发现的癌症增加75%，而诊断为良性疾病的手术减少70%。47例切除的癌症中有42例被纳入细胞组织学可能癌症组。这些癌症中只有29种在临床上被归类为癌症。两个未被细胞学诊断的癌症在组织学上被怀疑，反之亦然。所有51个切除的细胞组织学良性结节均为良性。细胞学检查的假阳性率高于组织学检查。（JAMA 241：481-484，1979）
The accuracy of diagnosis of 455 thyroid nodules evaluated by cytological and histological specimens obtained by fine- and large-needle biopsy, respectively, was compared with that for 1,094 nodules previously evaluated by clinical methods. The use of cytohistological data halved the number of patients with suspected cancer and doubled the number of patients to be observed. Cancers identified at operation for high and intermediate cancerrisk patients increased 75%, and operation for diagnosis of benign disease decreased 70%. Forty-two of 47 excised cancers were included in the cytohistological probable cancer group. Only 29 of these cancers were so classified clinically. Two cancers not diagnosed cytologically were suspected histologically and vice versa for one cancer. All 51 excised cytohistologically benign nodules were benign. There were more falsepositive findings with cytological than with histological specimens. ( JAMA 241:481-484, 1979)