New amide N-glycosides of ansamitocins identified from Actinosynnema pretiosum
New amide N-glycosides of ansamitocins identified from Actinosynnema pretiosum
复制标题
从 Actinosynnema pretiosum 中鉴定出新的安丝菌素酰胺 N-糖苷
DOI：
10.1007/bf02977625
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发表时间：
2007-06-01
影响因子：
6.7
通讯作者：
Shen, Yue-Mao
中科院分区：
文献类型：
--
作者：
Ma, Juan;Zhao, Pei-Ji;Shen, Yue-Mao
采用制备薄层色谱法从放射丝杆放线菌Actinosynema pretiosum中分离得到两个化合物，其中包括一个新的安丝菌素酰胺N-糖苷（2）。根据其光谱数据，将这些化合物鉴定为N-去甲基-N-β-D-吡喃葡萄糖基安丝菌素P-2，命名为安丝菌素P-2（1）和N-去甲基-N-β-D-吡喃葡萄糖基安丝菌素P-1，命名为安丝菌素P-1（2）。对1和2进行了1H-1-NMR和1C-13-NMR归属，同时对1的1C-13-NMR归属进行了修订。生物测定结果表明，1具有抗肿瘤活性。
By using preparative TLC as the critical isolation procedure, two compounds, including one new amide N-glycosides of ansamitocin (2), were isolated from Actinosynnema pretiosum. The compounds were elucidated as N-demethyl-N-beta-D-glucopyranosyl ansamitocin P-2, named ansamitocinoside P-2 (1), and N-demethyl-N-beta-D-glucopyranosyl ansamitocin P-1, named ansamitocinoside P-1 (2) on the basis of their spectral data. The H-1-NMR and C-13-NMR assignments were made for 1 and 2 while the C-13-NMR assignment for 1 was revised. Bioassay results showed that 1 had antineoplastic activity.