ActDES - a Curated Actinobacterial Database for Evolutionary Studies
ActDES - a Curated Actinobacterial Database for Evolutionary Studies
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ActDES - 用于进化研究的精选放线菌数据库
DOI：
10.1101/2020.05.20.105536
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Schniete J
中科院分区：
文献类型：
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作者：
Schniete J
放线菌是一个庞大而多样的细菌门，包含医学和生态相关的有机体。许多成员是生物活性天然产物和化学前体的宝贵来源，在临床中利用它们复杂基因组中编码的酶途径进行开发。虽然近20年来测序的基因组数量迅速增加，但许多放线菌基因组的大尺寸、复杂性和高G+C含量意味着序列仍然不完整，并且由大量缺乏注释的contigs组成，这阻碍了大规模的比较基因组和进化研究。为了更好地了解和利用放线菌基因组，必须将专门的基因组数据库与高质量的基因组序列联系起来。在这里，我们提供了一个来自80个属的612个高质量放线菌基因组的精选数据库，这些基因组被选择来代表一个广泛的系统发育组，具有等效的基因组重新注释。利用该数据库将为研究人员提供一个进化和代谢研究的框架，为基因组和代谢工程奠定基础，促进新的生物活性疗法的发现和基因家族进化的研究。本文包含由Microreact托管的数据。
Actinobacteriais a large and diverse phylum of bacteria that contains medically and ecologically relevant organisms. Many members are valuable sources of bioactive natural products and chemical precursors that are exploited in the clinic and made using the enzyme pathways encoded in their complex genomes. Whilst the number of sequenced genomes has increased rapidly in the last 20 years, the large size, complexity and high G+C content of many actinobacterial genomes means that the sequences remain incomplete and consist of large numbers of contigs with poor annotation, which hinders large-scale comparative genomic and evolutionary studies. To enable greater understanding and exploitation of actinobacterial genomes, specialized genomic databases must be linked to high-quality genome sequences. Here, we provide a curated database of 612 high-quality actinobacterial genomes from 80 genera, chosen to represent a broad phylogenetic group with equivalent genome re-annotation. Utilizing this database will provide researchers with a framework for evolutionary and metabolic studies, to enable a foundation for genome and metabolic engineering, to facilitate discovery of novel bioactive therapeutics and studies on gene family evolution. This article contains data hosted by Microreact.