EXCRETION PATTERNS OF CANNABINOID METABOLITES AFTER LAST USE IN A GROUP OF CHRONIC USERS
EXCRETION PATTERNS OF CANNABINOID METABOLITES AFTER LAST USE IN A GROUP OF CHRONIC USERS
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DOI：
10.1038/clpt.1985.226
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发表时间：
1985-01-01
影响因子：
6.7
通讯作者：
TASHCHIAN, A
中科院分区：
文献类型：
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作者：
ELLIS, GM;MANN, MA;TASHCHIAN, A
86慢性大麻使用者的尿液排泄模式进行了检查后，他们的最后一次大麻使用两种常见的筛查方法，半定量EMIT-d.a.u.和定性EMIT-st（Syva公司）。我们证明，在非常严格的监督下禁欲，长期使用者在EMIT-d.a.u.上尿液中大麻素的阳性结果为20 ng/ml或以上。检测从入院起长达连续46天，并且可能需要长达77天才能连续10天下降到低于截止校准品。所有受试者的平均排泄时间为27天。受试者排泄模式明显为双相，初始较高的排泄率未持续。在随后的平稳期内，大多数受试者有一个或多个单独的大麻素阴性尿液检测结果序列，平均持续3天，然后至少有一个阳性结果。人口统计学、体型和药物史变量被证明只是排泄模式的中度预测因子。结果进行了讨论的背景下，潜在的临床和法医应用。
The urinary excretion patterns of 86 chronic cannabis users were examined after their last cannabis use by two common screening methods, the semiquantitative EMIT-d.a.u. and the qualitative EMIT-st (Syva Company). We demonstrated that under very strictly supervised abstinence, chronic users can have positive results for cannabinoids in urine at 20 ng/ml or above on the EMIT-d.a.u. assay for as many as 46 consecutive days from admission, and can take as many as 77 days to drop below the cutoff calibrator for 10 consecutive days. For all subjects, the mean excretion time was 27 days. Subject excretion patterns were clearly biphasic, with initial higher rates of excretion not sustained. During the subsequent period of leveling off, most subjects had one or more separate sequences of cannabinoid-negative urine test results, lasting a mean of 3 days each and followed by at least one positive result. Demographic, body type, and drug history variables proved to be only moderate predictors of excretion patterns. Findings were discussed in the context of potential clinical and forensic application.