Estimation of Controlled Drug-release Behavior of Nano-porous Silica Micro Particles and Their Biocompatibility
Estimation of Controlled Drug-release Behavior of Nano-porous Silica Micro Particles and Their Biocompatibility
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纳米多孔二氧化硅微粒的控释行为及其生物相容性评估
作者：
Seitoku;E.;Era;Y.;Nakanishi;K.;Bando;Y.;Kakuda;S.;Nakamura;K.;Kusaka;T.;Abe;S.;Nakamura;M.;Yawaka;Y.;iida;J.;Yoshida;Y.;Sano;H.
在这项研究中，我们研究了一种模型药物从牙科玻璃离子水门合剂（GIC）中含有的纳米多孔二氧化硅微粒（NPSM）的控释行为。NPSM将模型药物分子加入GIC后，在水中逐渐释放2周。相比之下，只有gic的样品释放分子的速度很快。为了评估NPSM的细胞相容性，我们将成骨细胞暴露于不同浓度的颗粒中。在浓度为30ppm时，细胞活力与未暴露时相同。此外，混合颗粒不影响其力学性能。这些结果表明，NPSM可以作为一种可持续的释药牙科材料。
In this study, we investigated the controlled release behavior of a model drug from nanoporous silica microparticles (NPSM) contained in dental glass ionomer cement (GIC). NPSM released model drug molecules gradually in water for 2 weeks when they were contained in GIC. In contrast, GIC-only specimens released the molecule rapidly. To estimate the cytocompatibility of NPSM, osteoblastic cells were exposed to particles with various concentrations. At a concentration of 30 ppm, cell viability remained identical to that without exposure. In addition, mixing the particles did not affect their mechanical properties. These results suggest that NPSM can be used as a sustainable drug-release dental material.