Converting enzyme inhibition and progressive glomerulosclerosis in the rat.
Converting enzyme inhibition and progressive glomerulosclerosis in the rat.
复制标题
大鼠中的转化酶抑制和进行性肾小球硬化。
作者：
J. Beukers;A. F. van der Wal;P. Hoedemaeker;J. Weening
研究了卡托普利（CAP， 500 mg/l饮用水）对6组未肾切除（UN）雄性Wistar大鼠肾小球硬化（GS）发生发展的影响。在A组,接受联合国上限为4到5周后,降低收缩压(SBP)、滤过分数和肾小球卷被发现与对照组b .长期治疗与上限为8个月后联合国(C组)导致的SBP降低30毫米汞柱,低水平的蛋白尿和低发病率GS(0 1.5%)比控制老鼠(D组),与SBP的131 + / - 4毫米汞柱,在联合国后8个月，蛋白尿达到103 - 509毫克/天，GS达到9.1 - 29.7%。E组和F组在没有治疗的情况下随访至UN后7个月，此时出现高水平的蛋白尿。然后在E组开始CAP治疗，与对照组f相比，在UN后11个月，CAP治疗并没有降低收缩压、蛋白尿和GS。这项研究表明，早期CEI可以预防UN后大鼠进行性蛋白尿和GS，并与收缩压、滤过分数和肾小球体积的降低有关。一旦UN后大鼠出现高水平的蛋白尿和GS， CEI对收缩压没有影响，也对GS和蛋白尿的进展没有影响。
The effect of converting enzyme inhibition (CEI) by captopril (CAP, 500 mg/liter drinking water) on the development and progression of glomerulosclerosis (GS) was studied in six groups of male uninephrectomized (UN) Wistar rats. In group A, treated with CAP for four to five weeks after UN, a reduction in systolic blood pressure (SBP), filtration fraction and glomerular volumes was found as compared to control group B. Long-term treatment with CAP for eight months after UN (group C) resulted in lowering of SBP with 30 mm Hg, a low level of proteinuria and low incidence of GS (0 to 1.5%) as compared to control rats (group D), with SBP of 131 +/- 4 mm Hg, proteinuria up to 103 to 509 mg/day and 9.1 to 29.7% GS at eight months after UN. Groups E and F were followed without therapy up to seven months after UN, at which time a high level of proteinuria was present. CAP therapy then started in group E, did not reduce SBP, proteinuria and GS at 11 months after UN relative to control group F. This study shows that early CEI prevents progressive proteinuria and GS in rats after UN and is associated with a reduction in SBP, filtration fraction and glomerular volume. Once high levels of proteinuria and GS have developed in rats after UN, CEI has no effect on SBP nor on the progression of GS and proteinuria.
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影响因子：
158.5
作者：
BRENNER, BM;MEYER, TW;HOSTETTER, TH
通讯作者：
HOSTETTER, TH
抗凝药物对大鼠肾梗塞相关的进行性高血压和尿毒症的抑制作用。
影响因子：
7.5
作者：
Purkerson,ML;Joist,JH;Greenberg,JM;Kay,D;Hoffsten,PE;Klahr,S
通讯作者：
Klahr,S
饮食前列腺素前体对实验诱导的慢性肾衰竭进展的影响。
DOI：
--
发表时间：
1982
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Barcelli,UO;Weiss,M;Pollak,VE
通讯作者：
Pollak,VE
肾脏质量极度消融后，肾小球通透性发生改变，进行性硬化。
影响因子：
19.6
作者：
Olson,JL;Hostetter,TH;Rennke,HG;Brenner,BM;Venkatachalam,MA
通讯作者：
Venkatachalam,MA
抑制血栓素合成可改善肾次全消融大鼠的进行性肾病。
DOI：
10.1073/pnas.82.1.193
发表时间：
1985
影响因子：
11.1
作者：
Purkerson,ML;Joist,JH;Yates,J;Valdes,A;Morrison,A;Klahr,S
通讯作者：
Klahr,S