Single-unit responses to 22 kHz ultrasonic vocalizations in rat perirhinal cortex
Single-unit responses to 22 kHz ultrasonic vocalizations in rat perirhinal cortex
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DOI：
10.1016/j.bbr.2007.03.009
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发表时间：
2007-09-04
影响因子：
2.7
通讯作者：
Brown, Thomas Huntington
中科院分区：
文献类型：
--
作者：
Allen, Timothy Alexander;Furtak, Sharon Christine;Brown, Thomas Huntington
大鼠在几种情况下发出超声波发声（USV）作为社会信号。病变研究表明，大鼠周围皮层（PR）是一种与杏仁核相互关联的多层感觉区域，对于正常恐惧条件至关重要，对所谓的“ 22 kHz USV”至关重要。在这里，我们评估了大鼠PR中对22 kHz USV和其他声学刺激的单单元响应。一个问题是，PR电路是否在恐惧条件之前进行了专门和优先调整，以应对USV和USV样刺激。从不同的同种异体中预先录制了两个22 kHz USV。每个USV都由几个离散呼叫的“回合”组成。使用实验性幼稚的大鼠，将对USV的单单元响应与对具有与USV相同的根频率的连续或不连续音调的响应进行了比较（19或22 kHz）。不连续音调的ON/OFF模式将与相应USV中的呼叫结构进行时间匹配。与连续的音调相比，USV不太可能引起PR中的单个单元射击变化。另一方面，连续的音调和USV显然确实在许多单元中引起了不同的射击模式。更具体地说，USV有时会引起每次呼叫中每个呼叫的放电频率的瞬时增加。有趣的是。 USV和暂时匹配的音段通常会引起类似的射击模式。因此，PR中的USV引起的射击模式似乎是由呼叫的ON/OFF时间结构控制的，而不是通过呼叫回合中与每个呼叫相关的频率或振幅调制。 （c）2007 Elsevier B.V.保留所有权利。
Rats emit ultrasonic vocalizations (USVs) as social signals in several Situations. Lesion studies have shown that rat perirhinal cortex (PR), a polymodal sensory region that is reciprocally connected with the amygdala, is critical for normal fear conditioning to so-called "22 kHz USVs". Here we evaluated single-unit responses in rat PR to 22 kHz USVs and other acoustic stimuli. One question was whether PR circuits are specifically and preferentially tuned, prior to fear conditioning, to respond to USVs and USV-like stimuli. Two 22 kHz USVs were pre-recorded from different conspecifics. Each USV consisted of a "bout" of several discrete calls. Using experimentally naive rats, single-unit responses to the USVs were compared with responses to continuous or discontinuous tones that had the same root frequency as the USVs ( 19 or 22 kHz). The on/off patterns of the discontinuous tones were temporally matched to the call structure in the corresponding USVs. Compared to continuous tones, the USVs were no more likely to elicit single-unit firing changes in PR. On the other hand, the continuous tones and USVs clearly did elicit different firing patterns in many units. More specifically, the USVs sometimes elicited a transient increase in discharge frequency to each call in a bout of calls. Interestingly. the USVs and the temporally matched tone segments Usually elicited similar firing patterns. The USV-elicited firing pattern in PR thus appears to be controlled by the on/off temporal structure of the calls rather than by the frequency or amplitude modulations associated with each call in a bout of calls. (c) 2007 Elsevier B.V. All rights reserved.