Ventral striatal dopamine reflects behavioral and neural signatures of model-based control during sequential decision making
Ventral striatal dopamine reflects behavioral and neural signatures of model-based control during sequential decision making
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DOI：
10.1073/pnas.1417219112
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发表时间：
2015-02-03
影响因子：
11.1
通讯作者：
Schlagenhauf, Florian
中科院分区：
文献类型：
--
作者：
Deserno, Lorenz;Huys, Quentin J. M.;Schlagenhauf, Florian
双系统理论认为，行为控制是解析之间的审议“基于模型”和更自反的“无模型”系统。由这些系统施加的控制平衡被认为与多巴胺神经传递有关。然而，在缺乏对人类多巴胺的直接测量的情况下，仍然不知道这是否反映了纹状体或其他脑区中多巴胺的定量关系。使用功能性磁共振成像过程中进行的顺序决策任务，结合纹状体多巴胺的措施，使用[F-18]多巴正电子发射断层扫描，我们发现，更高的突触前腹侧纹状体多巴胺水平与行为偏向更多的模型为基础的控制。腹侧纹状体中较高的突触前多巴胺与外侧前额叶皮质中基于模型的特征的更多编码以及腹侧纹状体中无模型预测错误的编码减少有关。因此，腹侧纹状体突触前多巴胺的个体间变异反映了无模型和基于模型控制的行为表达和神经签名的平衡。我们的数据提供了一个新的视角，突触前多巴胺水平的改变可能伴随着行为控制的破坏，如在衰老或神经精神疾病，如精神分裂症和成瘾中观察到的。
Dual system theories suggest that behavioral control is parsed between a deliberative "model-based" and a more reflexive "model-free" system. A balance of control exerted by these systems is thought to be related to dopamine neurotransmission. However, in the absence of direct measures of human dopamine, it remains unknown whether this reflects a quantitative relation with dopamine either in the striatum or other brain areas. Using a sequential decision task performed during functional magnetic resonance imaging, combined with striatal measures of dopamine using [F-18]DOPA positron emission tomography, we show that higher presynaptic ventral striatal dopamine levels were associated with a behavioral bias toward more model-based control. Higher presynaptic dopamine in ventral striatum was associated with greater coding of model-based signatures in lateral prefrontal cortex and diminished coding of model-free prediction errors in ventral striatum. Thus, interindividual variability in ventral striatal presynaptic dopamine reflects a balance in the behavioral expression and the neural signatures of model-free and model-based control. Our data provide a novel perspective on how alterations in presynaptic dopamine levels might be accompanied by a disruption of behavioral control as observed in aging or neuropsychiatric diseases such as schizophrenia and addiction.