CELLS OF THE RAT LATERAL HABENULA RESPOND TO HIGH-THRESHOLD SOMATOSENSORY INPUTS
CELLS OF THE RAT LATERAL HABENULA RESPOND TO HIGH-THRESHOLD SOMATOSENSORY INPUTS
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DOI：
10.1016/0304-3940(89)90393-5
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发表时间：
1989-01-30
影响因子：
2.5
通讯作者：
JEAUGEY, L
中科院分区：
文献类型：
--
作者：
BENABID, AL;JEAUGEY, L
在麻醉大鼠中对单个神经元进行的细胞外电记录表明，外侧缰核中约三分之二的神经元对周围伤害性刺激有反应，其方式与中央中核复合体中的细胞类似，这些细胞可被激活（具有不同潜伏期的多个峰值）或被抑制。这些外侧缰核细胞的放电模式为兴奋性（75%）或抑制性（24%），且与刺激强度有关；它们的感受野较大且双侧分布。这些细胞中的大多数也对其他类型的伤害性刺激有反应，但对非伤害性刺激无反应。本研究有力地表明，外侧缰核是脑桥上部水平伤害性输入的一个中枢靶点。这一原创性发现与我们之前观察到的刺激缰核可诱导纳洛酮镇痛的结果一致，并提示该结构参与了伤害性输入的处理过程。
Extracellular electrical recordings of single units in the anaesthetized rat demonstrate that about two thirds of the neurons in the lateral habenula respond to peripheral noxious stimuli in a way similar to that of the cells in centrum-medianum complex which can be activated (with several peaks of various latencies) or inhibited. The firing pattern of these lateral habenula cells is excitatory (75%) or inhibitory (24%) and is related to the intensity of the stimulus; their receptive field is large and bilateral. Most of these cells also respond to other kinds of noxious but not to non-noxious stimuli. The present study strongly suggests that the lateral habenula is a central target at the upper brainstem level for nociceptive inputs. This original finding is consistent with our previous observation of naloxone analgesia induced by stimulation of the habenula and suggests an involvement of this structure in the processing of noxious inputs.