Pathology of dendrites in subacute spongiform virus encephalopathies.
Pathology of dendrites in subacute spongiform virus encephalopathies.
复制标题
亚急性海绵状病毒脑病树突的病理学。
作者：
P. Lampert;D. Gajdusek;C. Gibbs
用电子显微镜检查了瘙痒症小鼠和患有实验性库鲁病和克雅氏病的黑猩猩大脑皮层的海绵状变化。特征性发现包括神经元（尤其是树突）肿胀和空泡化。肿胀的细胞和突起发生融合。这些变化与质膜的改变有关。卷曲的膜碎片聚集在细胞融合点和树突内的空泡边缘。异常膜较正常质膜宽，嗜锇性强。这些发现以及其他关于痒病、库鲁病和克雅氏病的非典型病毒性质的数据表明，感染因子与细胞膜密切相关，神经元细胞膜的改变引发了神经元的海绵状变性。
The spongiform changes in the cerebral cortex of scrapie mice and of chimpanzees afflicted with experimental kuru and Creutzfeldt-Jakob disease were examined by electron microscopy. The pathognomonic findings consisted of swelling and vacuolation of neurons, particularly of dendrites. Fusion of swollen cells and processes occurred. The changes were associated with alterations of plasma membranes. Curled fragments of membranes accumulated at points of cell fusion and at the margin of vacuoles within dendrites. The abnormal membranes were wider and more osmiophilic than normal plasma membranes. These findings as well as other data on the nature of the atypical viruses of scrapies, kuru, and Creutzfeldt-Jakob disease indicate that the infectious agents are closely associated with membranes and that alterations of neuronal membranes initiate the spongiform degeneration of neurons.