Autoradiographic analysis of Schistosoma mansoni migration from skin to lungs in naive mice. Evidence that most attrition occurs after the skin phase.
Autoradiographic analysis of Schistosoma mansoni migration from skin to lungs in naive mice. Evidence that most attrition occurs after the skin phase.
复制标题
曼氏血吸虫在幼鼠体内从皮肤到肺部迁移的放射自显影分析。
DOI：
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发表时间：
1983
影响因子：
3.3
通讯作者：
D. A. Dean
中科院分区：
文献类型：
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作者：
B. Mangold;D. A. Dean
进行了一项研究，以确定曼氏血吸虫在感染第一周期间对幼稚小鼠（先天抵抗力）的消耗程度。每只小鼠均暴露于用[75Se]硒代蛋氨酸放射性标记的50个尾蚴。暴露后第 1、4 和 7 天，通过压缩器官放射自显影分析皮肤、肺和肝脏是否存在标记的幼虫。使用该技术确定，在尾蚴阶段和成虫阶段之间发生的 59% 损耗中，不超过三分之一可归因于皮阶段的损耗；幼虫迁移到肺部后，幼虫的大部分消耗发生了。
A study was performed to determine the extent of attrition of Schistosoma mansoni in naive mice (innate resistance) during the 1st week of infection. Each mouse was exposed to exactly 50 cercariae radiolabeled with [75Se] selenomethionine. On 1, 4, and 7 days postexposure, skin, lungs and liver were analyzed by compressed organ autoradiography for the presence of labeled larvae. Using this technique it was determined that no more than one-third of the 59% attrition that occurred between the cercarial and adult worm stages could be attributed to losses during the skin phase; most of the attrition in naive mice occurred after the migration of larvae to the lungs.