Sex differences in early outcomes after lung cancer resection: Analysis of the Society of Thoracic Surgeons General Thoracic Database
Sex differences in early outcomes after lung cancer resection: Analysis of the Society of Thoracic Surgeons General Thoracic Database
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DOI：
10.1016/j.jtcvs.2014.03.012
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发表时间：
2014-07-01
影响因子：
6
通讯作者：
D'Amico, Thomas A.
中科院分区：
文献类型：
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作者：
Tong, Betty C.;Kosinski, Andrzej S.;D'Amico, Thomas A.
目的：与男性相比，女性肺癌患者具有上级长期生存结局，与分期无关。这种差异的原因尚不清楚。对于接受肺癌切除术的患者，这些生存差异可能部分归因于女性围手术期结局相对较好。本研究旨在确定肺癌手术后围手术期结局的差异，基于性别。方法：查询2002年至2010年期间接受肺癌切除术的所有患者的胸外科医师协会通用胸外科数据库。根据性别分析术后并发症。进行单变量分析，然后进行多变量建模，以确定术后发病率和死亡率的显着危险因素。结果：共34,188例患者（16,643名男性和17,545名女性）被认为是。单变量分析表明，在所有类型的术后并发症中，术后并发症的统计学显著差异有利于女性。女性患者的住院死亡率和30天死亡率也较低（比值比，0.56; 95%可信区间，0.44-0.71; P
Objectives: Women with lung cancer have superior long-term survival outcomes compared with men, independent of stage. The cause of this disparity is unknown. For patients undergoing lung cancer resection, these survival differences could be due, in part, to relatively better perioperative outcomes for women. This study was undertaken to determine differences in perioperative outcomes after lung cancer surgery on the basis of sex.Methods: The Society of Thoracic Surgeons' General Thoracic Database was queried for all patients undergoing resection of lung cancer between 2002 and 2010. Postoperative complications were analyzed with respect to sex. Univariable analysis was performed, followed by multivariable modeling to determine significant risk factors for postoperative morbidity and mortality.Results: A total of 34,188 patients (16,643 men and 17,545 women) were considered. Univariable analysis demonstrated statistically significant differences in postoperative complications favoring women in all categories of postoperative complications. Women also had lower in-hospital and 30-day mortality (odds ratio, 0.56; 95% confidence interval, 0.44-0.71; P